CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis

• Published in: Rheumatology (Oxford, England) Vol. 48; no. 12; pp. 1502 - 1505
• Main Authors: Kamesh, Lavanya, Heward, Joanne M., Williams, Julie M., Gough, Stephen C. L., Chavele, Konstantia-Maria, Salama, Alan, Pusey, Charles, Savage, Caroline O. S., Harper, Lorraine
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.12.2009
• Subjects: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology; Antigens, CD - genetics; Biological and medical sciences; Case-Control Studies; CTLA-4; CTLA-4 Antigen; Diseases of the osteoarticular system; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Medical sciences; Polymorphism, Single Nucleotide; Polymorphisms; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Vasculitis; Vascular disease; Vasculitis; Antineutrophil cytoplasmic antibody; Blood vessel; Rheumatology; Cardiovascular disease; CTLA-4; Polymorphisms; Polymorphism

Objective. To investigate whether single nucleotide polymorphisms (SNPs) within cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with ANCA-associated small vessel vasculitis (SVV). Methods. The CTLA-4 CT60 (exon 4), +49 (exon 1) and −318 (promoter region) genotypes were determined by PCR and...