Ceftazidime-Avibactam: a Novel Cephalosporin/β-lactamase Inhibitor Combination

• Published in: Drugs (New York, N.Y.) Vol. 73; no. 2; pp. 159 - 177
• Main Authors: Zhanel, George G., Lawson, Christopher D., Adam, Heather, Schweizer, Frank, Zelenitsky, Sheryl, Lagacé-Wiens, Philippe R. S., Denisuik, Andrew, Rubinstein, Ethan, Gin, Alfred S., Hoban, Daryl J., Lynch, Joseph P., Karlowsky, James A.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing AG 01.02.2013; Adis International
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Azabicyclo Compounds - chemistry; Azabicyclo Compounds - pharmacology; Azabicyclo Compounds - therapeutic use; Bacterial Infections - drug therapy; beta-Lactamase Inhibitors; Biological and medical sciences; Ceftazidime - chemistry; Ceftazidime - pharmacology; Ceftazidime - therapeutic use; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Internal Medicine; Medical sciences; Medicine; Medicine & Public Health; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Review Article; AmpC; Meropenem; Complicated Urinary Tract Infection; Ceftaroline; Ceftazidime; Human; Drug combination; Treatment resistance; Enzyme; Indication; Toxicity; β-Lactams; Treatment efficiency; Enzyme inhibitor; Avibactam; β-Lactamase; Review; Biological activity; Antibiotic; Chemistry; Cephalosporin derivatives; β-Lactamases inhibitor; Animal; Hydrolases; Clinical trial; Antibacterial agent; Mechanism of action; Pharmacokinetics

Avibactam (formerly NXL104, AVE1330A) is a synthetic non-β-lactam, β-lactamase inhibitor that inhibits the activities of Ambler class A and C β-lactamases and some Ambler class D enzymes. This review summarizes the existing data published for ceftazidime-avibactam, including relevant chemistry, mech...