A multifunctional catalyst that stereoselectively assembles prodrugs
The catalytic stereoselective synthesis of compounds with chiral phosphorus centers remains an unsolved problem. State-of-the-art methods rely on resolution or stoichiometric chiral auxiliaries. Phosphoramidate prodrugs are a critical component of pronucleotide (ProTide) therapies used in the treatm...
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Published in | Science (American Association for the Advancement of Science) Vol. 356; no. 6336; pp. 426 - 430 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for the Advancement of Science
28.04.2017
The American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
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