CTLA-4 regulates T follicular regulatory cell differentiation and participates in intestinal damage caused by spontaneous autoimmunity

• Published in: Biochemical and biophysical research communications Vol. 505; no. 3; pp. 865 - 871
• Main Authors: Chao, Gao, Li, Xiaoli, Ji, Yahong, Zhu, Ying, Li, Na, Zhang, Nana, Feng, Zunyong, Niu, Min
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.11.2018
• Subjects: 60 APPLIED LIFE SCIENCES; Animals; autoantibodies; Autoimmunity; B-lymphocytes; B-Lymphocytes - immunology; CD4-Positive T-Lymphocytes; CELL DIFFERENTIATION; CMV virus; Crohn disease; CTLA-4; CTLA-4 Antigen - deficiency; CTLA-4 Antigen - genetics; CTLA-4 Antigen - physiology; cytotoxicity; death; Follicular treg; Germinal Center; Humans; IBD; immune response; Immunity, Humoral; immunosuppression; INFLAMMATION; intestinal mucosa; Intestines - immunology; Intestines - pathology; LYMPHOCYTES; MICE; Murid betaherpesvirus 1; mutation; patients; T-Lymphocytes, Regulatory - cytology; VIRUSES; Autoimmunity; CTLA-4; IBD; Follicular treg; CMV virus

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is a co-inhibitory molecule expressed by T cells and is required for immune regulation and inflammation prevention. In clinical patients, the CTLA-4 mutation causes spontaneous immune-related early-onset Crohn's disease; however, its potentia...