Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

• Published in: The Journal of biological chemistry Vol. 279; no. 43; pp. 44945 - 44954
• Main Authors: Vetrivel, Kulandaivelu S., Cheng, Haipeng, Lin, William, Sakurai, Takashi, Li, Tong, Nukina, Nobuyuki, Wong, Philip C., Xu, Huaxi, Thinakaran, Gopal
• Format: Journal Article
• Language: English
• Published: United States 22.10.2004
• Subjects: Adaptor Proteins, Vesicular Transport - metabolism; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biological Transport; Cell Line, Tumor; Cholesterol - chemistry; Detergents - pharmacology; Endocytosis; Endopeptidases - metabolism; Endosomes - metabolism; Fibroblasts - metabolism; Golgi Apparatus - metabolism; HeLa Cells; Humans; Intracellular Membranes - enzymology; Lipids - chemistry; Magnetics; Membrane Glycoproteins - chemistry; Membrane Microdomains - chemistry; Membrane Microdomains - enzymology; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Mutation; Neurons - metabolism; Peptide Hydrolases; Qa-SNARE Proteins; R-SNARE Proteins; Subcellular Fractions; Sucrose - pharmacology; Transgenes

Alzheimer's disease-associated beta-amyloid peptides (Abeta) are generated by the sequential proteolytic processing of amyloid precursor protein (APP) by beta- and gamma-secretases. There is growing evidence that cholesterol- and sphingolipid-rich membrane microdomains are involved in regulatin...