Common pathogenic mechanisms and pathways in the development of COPD and lung cancer

• Published in: Expert opinion on therapeutic targets Vol. 15; no. 4; p. 439
• Main Authors: Yang, Ian A, Relan, Vandana, Wright, Casey M, Davidson, Morgan R, Sriram, Krishna B, Savarimuthu Francis, Santiyagu M, Clarke, Belinda E, Duhig, Edwina E, Bowman, Rayleen V, Fong, Kwun M
• Format: Journal Article
• Language: English
• Published: England 01.04.2011
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - epidemiology; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma of Lung; Epigenesis, Genetic; Female; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - epidemiology; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Molecular Targeted Therapy; Polymorphism, Single Nucleotide; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - pathology; Smoking; Smoking Cessation

Lung cancer and COPD commonly coexist in smokers, and the presence of COPD increases the risk of developing lung cancer. In addition to smoking cessation and preventing smoking initiation, understanding the shared mechanisms of these smoking-related lung diseases is critical, in order to develop new...