Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting

• Published in: Pharmacological research Vol. 192; p. 106781
• Main Authors: Shen, Ying, Jin, Shi-jie, Chen, Yi-chang, Liu, Wen-hui, Li, Yi-ming, Zhao, Wen-yi, Xu, Ying-chun, Chen, Shu-qing, Zhao, Wen-bin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2023; Elsevier
• Subjects: Dual tumor-targeting; Interdomain configurations; Logic-gate; Trispecific T cell engagers; Tumor selectivity; HEK293T; TCR; TriTCEs; Dual tumor-targeting; ATCC; Interdomain configurations; LDH; MFI; IFN-γ; FBS; EC50; FRET; TCEs; HEK293F; Logic-gate; Trispecific T cell engagers; Tumor selectivity; IL-2; PBMCs; TCRm; TAA; pHLA; SLL/A2; HLA; RMF/A2

Targeting single tumor antigens makes it difficult to provide sufficient tumor selectivity for T cell engagers (TCEs), leading to undesirable toxicity and even treatment failure, which is particularly serious in solid tumors. Here, we designed novel trispecific TCEs (TriTCEs) to improve the tumor se...