The CD8 + Memory Stem T Cell (T SCM ) Subset Is Associated with Improved Prognosis in Chronic HIV-1 Infection

• Published in: Journal of virology Vol. 88; no. 23; pp. 13836 - 13844
• Main Authors: Ribeiro, Susan P., Milush, Jeffrey M., Cunha-Neto, Edecio, Kallas, Esper G., Kalil, Jorge, Somsouk, Ma, Hunt, Peter W., Deeks, Steven G., Nixon, Douglas F., SenGupta, Devi
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.12.2014
• Subjects: Adult; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cohort Studies; Cross-Sectional Studies; Female; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; Immunologic Memory; Male; Middle Aged; Pathogenesis and Immunity; Prognosis; Stem Cells - immunology

Memory stem T cells (T SCM ) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. The hallmarks of HIV-1 pathogenesis are CD4 + T cell depletion and abnormal cellular activation. We investigated the impact of HIV-1 infection on the T SCM...