Duchenne muscular dystrophy: do both parents contribute genetically to the disease?

• Published in: Journal of the neurological sciences Vol. 82; no. 1; pp. 245 - 255
• Main Authors: Field, E.J., Joyce, Greta
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.12.1987; Elsevier Science
• Subjects: Adolescent; Arachidonic Acid; Arachidonic Acids - pharmacology; Autosomal recessive nature; Biological and medical sciences; Child; Child, Preschool; Diseases of striated muscles. Neuromuscular diseases; Duchenne muscular dystrophy; Duchenne's muscular dystrophy; Electrophoresis; Electrophoretic mobility; Erythrocyte Membrane - analysis; Erythrocyte Membrane - drug effects; erythrocytes; Erythrocytes, Abnormal - analysis; Erythrocytes, Abnormal - drug effects; Female; Genes, Recessive; Genetic Carrier Screening; Humans; Linoleic Acid; Linoleic Acids - pharmacology; Male; man; Medical sciences; membranes; Muscular Dystrophies - blood; Muscular Dystrophies - genetics; Neurology; Red blood cells; Red blood cells; Autosomal recessive nature; Duchenne muscular dystrophy; Electrophoretic mobility; Nervous system diseases; Inheritance

By observing the effect of 0.08 and 0.02 mg/ml linoleic acid (LA) on the electrophoretic mobility of fresh red blood cells derived from the parents of a subject with DMD, it has been shown that all of 16 fathers as well as 15 mothers, consistently differ from normal. In normal subjects, whilst 0.08...