Gene circuit designs for noisy excitable dynamics

• Published in: Mathematical biosciences Vol. 231; no. 1; pp. 90 - 97
• Main Authors: Rue, Pau, Garcia-Ojalvo, Jordi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2011
• Subjects: Activator–repressor circuits; Excitable dynamics; Gene Regulatory Networks - genetics; genes; Hopf bifurcation; Kinetics; Models, Genetic; Noise; protein synthesis; Saddle-homoclinic bifurcation; SNIC bifurcation; Systems Biology; topology; SNIC bifurcation; Activator–repressor circuits; Hopf bifurcation; Noise; Excitable dynamics; Saddle-homoclinic bifurcation

► Gene circuits may exhibit two types of excitability, with distinct frequency behavior. ► The different frequency behaviors are associated with distinct bifurcations. ► The two excitability types respond differently to noise. ► Excitability types are not linked to any particular gene circuit archit...