Are umami taste receptor sites structurally related to glutamate CNS receptor sites?

• Published in: Physiology & behavior Vol. 49; no. 5; p. 905
• Main Author: Faurion, A
• Format: Journal Article
• Language: English
• Published: United States 01.05.1991
• Subjects: Amino Acids - physiology; Animals; Brain - physiology; Brain Mapping; Chorda Tympani Nerve - physiology; Cricetinae; Evoked Potentials, Somatosensory - physiology; Glutamates - physiology; Glutamic Acid; Guanosine Monophosphate; Humans; Male; Receptors, Glutamate; Receptors, Neurotransmitter - physiology; Sodium Glutamate; Structure-Activity Relationship; Taste - physiology; Taste Buds - physiology; Taste Threshold

Umami tasting substances, MSG (monosodium glutamate), HG (glutamic acid), LGDE (1-glutamic acid diethyl ester), DLHCA (dl-homocysteic acid), DLAAA (dl-aminoadipic acid) and 5'GMP, were tested on the hamster and the human. Ten mM MSG was routinely used in the hamster as it elicited strong chorda...