Shift in Monocyte Apoptosis with Increasing Viral Load and Change in Apoptosis-Related ISG/Bcl2 Family Gene Expression in Chronically HIV-1-Infected Subjects

• Published in: Journal of virology Vol. 89; no. 1; pp. 799 - 810
• Main Authors: Patro, Sean C., Pal, Sharmistha, Bi, Yingtao, Lynn, Kenneth, Mounzer, Karam C., Kostman, Jay R., Davuluri, Ramana V., Montaner, Luis J.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.01.2015
• Subjects: Adult; Aged, 80 and over; Apoptosis; Chronic Disease; Female; Gene Expression Profiling; HIV Infections - immunology; HIV Infections - virology; HIV-1 - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Male; Middle Aged; Monocytes - immunology; Monocytes - physiology; Pathogenesis and Immunity; Proto-Oncogene Proteins c-bcl-2 - biosynthesis; Retinoblastoma Protein - biosynthesis; Viral Load; Young Adult

Although monocytes and macrophages are targets of HIV-1-mediated immunopathology, the impact of high viremia on activation-induced monocyte apoptosis relative to monocyte and macrophage activation changes remains undetermined. In this study, we determined constitutive and oxidative stress-induced mo...