Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers

• Published in: Clinical chemistry and laboratory medicine Vol. 59; no. 8; pp. 1444 - 1452
• Main Authors: Padoan, Andrea, Bonfante, Francesco, Cosma, Chiara, Di Chiara, Costanza, Sciacovelli, Laura, Pagliari, Matteo, Bortolami, Alessio, Costenaro, Paola, Musso, Giulia, Basso, Daniela, Giaquinto, Carlo, Plebani, Mario
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 27.07.2021; Walter De Gruyter & Company
• Subjects: Antibodies; Assaying; clinical performances; Coronaviruses; COVID-19; Evaluation; Immunoassays; Immunoglobulin G; Mathematical analysis; Neutralization; Neutralizing; Pandemics; plaque reduction neutralization test; SARS-CoV-2; Serology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Viral diseases; SARS-CoV-2; neutralization; clinical performances; serology; plaque reduction neutralization test; immunoassays; antibodies

SARS-CoV-2 serology presents an important role in several aspects of COVID-19 pandemic. Immunoassays performances have to be accurately evaluated and correlated with neutralizing antibodies. We investigated the analytical and clinical performances of a SARS-CoV-2 RBD IgG assay, automated on a high t...