Host Cytokine Storm Is Associated With Disease Severity of Severe Fever With Thrombocytopenia Syndrome

• Published in: The Journal of infectious diseases Vol. 206; no. 7; pp. 1085 - 1094
• Main Authors: Sun, Yulan, Jin, Cong, Zhan, Faxian, Wang, Xianjun, Liang, Mifang, Zhang, Quanfu, Ding, Shujun, Guan, Xuhua, Huo, Xixiang, Li, Chuan, Qu, Jing, Wang, Qin, Zhang, Shuo, Zhang, Yanping, Wang, Shiwen, Xu, Anqiang, Bi, Zhenqiang, Li, Dexin
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2012
• Subjects: Acute diseases; Aged; Antibodies, Viral - blood; Biological and medical sciences; Bunyaviridae Infections - blood; Bunyaviridae Infections - immunology; Bunyaviridae Infections - mortality; Cluster Analysis; Cytokines; Cytokines - blood; Ebola virus; Female; Fever; Fundamental and applied biological sciences. Psychology; Host-Pathogen Interactions; Humans; Immunoglobulin G - blood; Infections; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; Phlebovirus - genetics; Phlebovirus - immunology; Thrombocytopenia; Viral diseases; Viral infections; Viral Load; Viruses; Infection; Thrombocytopenia; Platelet; Hemopathy; Fever; Cytokine

Background. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in China, caused by SFTS virus (SFTSV). Severe SFTS patients can quickly proceed to multiorgan dysfunction and death; however, underlying pathogenic mechanisms remain unclear. Methods. Serum samples from 15 f...