“Anti-idiotypic” antibodies to HLA in transiently sensitized DST patients

• Published in: Human immunology Vol. 26; no. 1; pp. 17 - 26
• Main Authors: Pohanka, Erich, Manfro, Roberto C., Oto, Carrie, Colombe, Beth W., Melzer, Juliet S., Feduska, Nicholas, Salvatierra, Oscar, Gorovoy, Marvin R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.1989; Elsevier Science
• Subjects: Adult; Antibodies, Anti-Idiotypic - biosynthesis; Biological and medical sciences; Blood Transfusion; Cytotoxicity Tests, Immunologic; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; HLA Antigens - immunology; Humans; Immunization; Kidney Transplantation; Male; Middle Aged; Time Factors; Tissue, organ and graft immunology; Human; Flow cytometry; HLA-System; Alloantigen; Immune response; Lymphocytotoxicity test; Transfusion; Antibody; Graft; Sensitization; Kidney

To test the hypothesis whether “anti-idiotypic” antibodies (Ab2) were involved in the loss of sensitization following donor-specific blood transfusions (DST), we investigated nine potential kidney graft recipients who became transiently sensitized after DST. Inhibiting “anti-idiotypic” activity of p...