Parathyroid hormone 1–34, but not 3–34 or 7–34, transiently translocates protein kinase C in cultured renal (OK) cells

• Published in: Biochemical and biophysical research communications Vol. 159; no. 3; pp. 1352 - 1358
• Main Authors: Tamura, Teiichi, Sakamoto, Hisato, Filburn, Charles R.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 31.03.1989; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Line; Cell physiology; Fundamental and applied biological sciences. Psychology; Hormonal regulation; Kidney - enzymology; Kinetics; Molecular and cellular biology; Opossums; Parathyroid Hormone - pharmacology; Peptide Fragments - pharmacology; Protein Kinase C - metabolism; Protein Kinases - metabolism; Structure-Activity Relationship; Teriparatide; Hormone; Proteins; Cell culture; Vertebrata; Protein kinase C; Mammalia; Calcium; Rodentia; Activation; Biological activity; Kidney

While protein kinase C (PKC) appears to play a role in the action of PTH in renal cells, direct evidence of activation by PTH is lacking. Rat PTH (1–34) caused a rapid, transient translocation of PKC in opossum kidney (OK) cells from a basal value of 0.09 to maximum of 0.24 at 10–15 sec. Both the ti...