Adenocarcinoma arising in gastric inverted hyperplastic polyp: A case report and review of the literature

A 54-year-old man, found to have a submucosal tumor in the stomach by double contrast roentgenography, endoscopy, and endoscopic ultrasonography, underwent a laparoscopic partial gastrectomy. The pathological examination revealed that the lesion, measuring 45 mm×35 mm, was an inverted hyperplastic p...

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Published inPathology, research and practice Vol. 203; no. 1; pp. 53 - 56
Main Authors Kono, Tokuyuki, Imai, Yasuo, Ichihara, Takao, Miyagawa, Kasumi, Kanemitsu, Kiyonori, Ajiki, Tetsuo, Kawasaki, Kentaro, Kamigaki, Takashi, Ikuta, Hajime, Ohbayashi, Chiho, Yokozaki, Hiroshi, Fujimori, Takahiro, Kuroda, Yoshikazu
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.01.2007
Subjects
Adenocarcinoma
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Biomarkers, Tumor - metabolism
Gastric Mucosa - pathology
Humans
Hyperplasia
Inverted hyperplastic polyp
Male
Middle Aged
p53
Polyps - metabolism
Polyps - pathology
Polyps - surgery
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Precancerous Conditions - surgery
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Treatment Outcome
Adenocarcinoma
Inverted hyperplastic polyp
p53
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Abstract A 54-year-old man, found to have a submucosal tumor in the stomach by double contrast roentgenography, endoscopy, and endoscopic ultrasonography, underwent a laparoscopic partial gastrectomy. The pathological examination revealed that the lesion, measuring 45 mm×35 mm, was an inverted hyperplastic polyp (IHP) located in the submucosal layer and consisting mostly of columnar cells resembling foveolar epithelium and pyloric gland cells. Notably, adenocarcinoma with adjacent dysplasia was observed in the submucosal glands. Transition from hyperplasia to dysplasia and from dysplasia to adenocarcinoma was noted. The adenocarcinoma component was intensely and diffusely positive for p53 overexpression, while the dysplasia component showed only weak and focal positivity, suggesting a role of p53 mutation in the dysplasia–carcinoma sequence. Gastric IHP is very rare, and only 31 cases (in 29 patients) have been reported. Five of these IHPs coexisted with gastric adenocarcinomas, which had all developed separately from the IHP lesions. Therefore, this is the first case of adenocarcinoma arising within gastric IHP itself.
AbstractList A 54-year-old man, found to have a submucosal tumor in the stomach by double contrast roentgenography, endoscopy, and endoscopic ultrasonography, underwent a laparoscopic partial gastrectomy. The pathological examination revealed that the lesion, measuring 45 mm x 35 mm, was an inverted hyperplastic polyp (IHP) located in the submucosal layer and consisting mostly of columnar cells resembling foveolar epithelium and pyloric gland cells. Notably, adenocarcinoma with adjacent dysplasia was observed in the submucosal glands. Transition from hyperplasia to dysplasia and from dysplasia to adenocarcinoma was noted. The adenocarcinoma component was intensely and diffusely positive for p53 overexpression, while the dysplasia component showed only weak and focal positivity, suggesting a role of p53 mutation in the dysplasia-carcinoma sequence. Gastric IHP is very rare, and only 31 cases (in 29 patients) have been reported. Five of these IHPs coexisted with gastric adenocarcinomas, which had all developed separately from the IHP lesions. Therefore, this is the first case of adenocarcinoma arising within gastric IHP itself.
A 54-year-old man, found to have a submucosal tumor in the stomach by double contrast roentgenography, endoscopy, and endoscopic ultrasonography, underwent a laparoscopic partial gastrectomy. The pathological examination revealed that the lesion, measuring 45 mm×35 mm, was an inverted hyperplastic polyp (IHP) located in the submucosal layer and consisting mostly of columnar cells resembling foveolar epithelium and pyloric gland cells. Notably, adenocarcinoma with adjacent dysplasia was observed in the submucosal glands. Transition from hyperplasia to dysplasia and from dysplasia to adenocarcinoma was noted. The adenocarcinoma component was intensely and diffusely positive for p53 overexpression, while the dysplasia component showed only weak and focal positivity, suggesting a role of p53 mutation in the dysplasia–carcinoma sequence. Gastric IHP is very rare, and only 31 cases (in 29 patients) have been reported. Five of these IHPs coexisted with gastric adenocarcinomas, which had all developed separately from the IHP lesions. Therefore, this is the first case of adenocarcinoma arising within gastric IHP itself.
Author Ajiki, Tetsuo
Fujimori, Takahiro
Kanemitsu, Kiyonori
Imai, Yasuo
Kuroda, Yoshikazu
Ichihara, Takao
Kamigaki, Takashi
Ohbayashi, Chiho
Kawasaki, Kentaro
Kono, Tokuyuki
Yokozaki, Hiroshi
Ikuta, Hajime
Miyagawa, Kasumi
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  givenname: Takashi
  surname: Kamigaki
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  organization: Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Japan
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  givenname: Takahiro
  surname: Fujimori
  fullname: Fujimori, Takahiro
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– sequence: 13
  givenname: Yoshikazu
  surname: Kuroda
  fullname: Kuroda, Yoshikazu
  organization: Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Japan
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Inverted hyperplastic polyp
p53
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Snippet A 54-year-old man, found to have a submucosal tumor in the stomach by double contrast roentgenography, endoscopy, and endoscopic ultrasonography, underwent a...
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SubjectTerms Adenocarcinoma
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Biomarkers, Tumor - metabolism
Gastric Mucosa - pathology
Humans
Hyperplasia
Inverted hyperplastic polyp
Male
Middle Aged
p53
Polyps - metabolism
Polyps - pathology
Polyps - surgery
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Precancerous Conditions - surgery
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Treatment Outcome
Title Adenocarcinoma arising in gastric inverted hyperplastic polyp: A case report and review of the literature
URI https://dx.doi.org/10.1016/j.prp.2006.08.010
https://www.ncbi.nlm.nih.gov/pubmed/17097828
https://search.proquest.com/docview/68959416
Volume 203
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