Context-dependent neuronal differentiation and germ layer induction of Smad4 −/− and Cripto −/− embryonic stem cells

Activation of transforming growth factor-β (TGF-β) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural fates. In vitro differentiated mouse embryonic stem (ES) cells with deletion of the TGF-β pathway-related factors Smad4 or Cripto exhibited increas...

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Published inMolecular and cellular neuroscience Vol. 28; no. 3; pp. 417 - 429
Main Authors Sonntag, Kai-Christian, Simantov, Rabi, Björklund, Lars, Cooper, Oliver, Pruszak, Jan, Kowalke, Florian, Gilmartin, Jocelyn, Ding, Jixiang, Hu, Ya-Ping, Shen, Michael M., Isacson, Ole
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2005
Subjects
Animals
Brain - cytology
Brain - embryology
Brain - metabolism
Cell Differentiation - physiology
Cell Lineage - physiology
DNA-Binding Proteins - genetics
Dopamine - metabolism
Ectoderm - cytology
Ectoderm - metabolism
Embryonic Induction - physiology
Epidermal Growth Factor - genetics
Germ Layers - cytology
Germ Layers - metabolism
Membrane Glycoproteins - genetics
Mesoderm - cytology
Mesoderm - metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasm Proteins - genetics
Neurons - cytology
Neurons - metabolism
Phenotype
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Serotonin - metabolism
Signal Transduction - physiology
Smad4 Protein
Stem Cell Transplantation - methods
Trans-Activators - genetics
Transforming Growth Factor beta - metabolism
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Abstract Activation of transforming growth factor-β (TGF-β) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural fates. In vitro differentiated mouse embryonic stem (ES) cells with deletion of the TGF-β pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons. Cripto −/− ES cells developed into neuroecto-/epidermal cell types, while Smad4 −/− cells also displayed mesodermal differentiation. ES cell differentiation into catecholaminergic neurons showed that these ES cells retained their ability to develop into dopaminergic and serotonergic neurons with typical expression patterns of midbrain and hindbrain genes. In vivo, transplanted ES cells to the mouse striatum became small neuronal grafts, or large grafts with cell types from all germ layers independent of their ES cell genotype. This demonstrates that Smad4 −/− and Cripto −/− ES cells favor a neural fate in vitro, but also express the mesodermal phenotype, implying that deletion of either Smad4 or Cripto is not sufficient to block nonneuronal tissue formation.
AbstractList Activation of transforming growth factor-beta (TGF-beta) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural fates. In vitro differentiated mouse embryonic stem (ES) cells with deletion of the TGF-beta pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons. Cripto-/- ES cells developed into neuroecto-/epidermal cell types, while Smad4-/- cells also displayed mesodermal differentiation. ES cell differentiation into catecholaminergic neurons showed that these ES cells retained their ability to develop into dopaminergic and serotonergic neurons with typical expression patterns of midbrain and hindbrain genes. In vivo, transplanted ES cells to the mouse striatum became small neuronal grafts, or large grafts with cell types from all germ layers independent of their ES cell genotype. This demonstrates that Smad4-/- and Cripto-/- ES cells favor a neural fate in vitro, but also express the mesodermal phenotype, implying that deletion of either Smad4 or Cripto is not sufficient to block nonneuronal tissue formation.
Activation of transforming growth factor-β (TGF-β) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural fates. In vitro differentiated mouse embryonic stem (ES) cells with deletion of the TGF-β pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons. Cripto −/− ES cells developed into neuroecto-/epidermal cell types, while Smad4 −/− cells also displayed mesodermal differentiation. ES cell differentiation into catecholaminergic neurons showed that these ES cells retained their ability to develop into dopaminergic and serotonergic neurons with typical expression patterns of midbrain and hindbrain genes. In vivo, transplanted ES cells to the mouse striatum became small neuronal grafts, or large grafts with cell types from all germ layers independent of their ES cell genotype. This demonstrates that Smad4 −/− and Cripto −/− ES cells favor a neural fate in vitro, but also express the mesodermal phenotype, implying that deletion of either Smad4 or Cripto is not sufficient to block nonneuronal tissue formation.
Author Björklund, Lars
Sonntag, Kai-Christian
Ding, Jixiang
Simantov, Rabi
Isacson, Ole
Cooper, Oliver
Gilmartin, Jocelyn
Pruszak, Jan
Kowalke, Florian
Hu, Ya-Ping
Shen, Michael M.
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Cites_doi 10.1073/pnas.90.18.8424
10.1006/dbio.2001.0289
10.1101/gad.14.6.627
10.1126/science.287.5457.1442
10.1038/292154a0
10.1016/S0959-4388(00)00171-9
10.1038/nn747
10.1016/S0092-8674(00)81556-1
10.1016/S1534-5807(01)00076-4
10.1128/MCB.22.13.4439-4449.2002
10.1038/nrn786
10.2165/00063030-200216060-00001
10.1006/dbio.1999.9430
10.1038/27215
10.1016/S0959-437X(00)00096-4
10.1038/nrn809
10.1073/pnas.022438099
10.1016/0963-6897(95)02040-3
10.1242/dev.126.1.137
10.1073/pnas.78.12.7634
10.1242/dev.121.11.3877
10.1038/nature00900
10.1038/343657a0
10.1038/nbt870
10.1006/dbio.2001.0350
10.1002/ana.10482
10.1101/gad.14.4.464
10.1016/j.ydbio.2003.08.023
10.1016/S0959-437X(02)00346-5
10.1046/j.1440-169X.2001.00599.x
10.1016/S0925-4773(01)00648-7
10.1101/gad.12.1.107
10.1016/S0896-6273(01)00263-X
10.1046/j.1460-9568.2002.02255.x
10.1016/S0378-1119(01)00892-7
10.1038/76536
10.1016/S1359-6101(99)00028-3
10.1016/S0168-9525(00)02006-0
10.1073/pnas.95.7.3667
10.1006/exnr.1997.6674
10.1385/NMM:2:3:233
10.1016/S0896-6273(00)00083-0
10.1038/326292a0
10.1128/MCB.22.8.2586-2597.2002
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References Nagy, Rossant, Nagy, Abramow-Newerly, Roder (bib27) 1993; 90
Yan, Liu, Luo, Haltiwanger, Abate-Shen, Shen (bib44) 2002; 22
Massague, Chen (bib23) 2000; 14
Oxburgh, Robertson (bib28) 2002; 112
Shen, Schier (bib33) 2000; 16
Tropepe, Hitoshi, Sirard, Mak, Rossant, van der Kooy (bib37) 2001; 30
Hooper, Hardy, Handyside, Hunter, Monk (bib12) 1987; 326
Kim, Auerbach, Rodriguez-Gomez, Velasco, Gavin, Lumelsky, Lee, Nguyen, Sanchez-Pernaute, Bankiewicz, McKay (bib16) 2002; 418
Soudais, Bielinska, Heikinheimo, MacArthur, Narita, Saffitz, Simon, Leiden, Wilson (bib35) 1995; 121
Weissman (bib38) 2000; 287
Kawasaki, Mizuseki, Nishikawa, Kaneko, Kuwana, Nakanishi, Nishikawa, Sasai (bib15) 2000; 28
Rossi, Cattaneo (bib31) 2002; 3
Whitman (bib40) 2001; 1
Schier, Talbot (bib32) 2001; 45
Wilkinson, Bhatt, Herrmann (bib41) 1990; 343
Yang, Li, Xu, Deng (bib45) 1998; 95
Liguori, Echevarria, Improta, Signore, Adamson, Martinez, Persico (bib46) 2003; 264
Daley (bib6) 2002; 12
Cai, Rao (bib4) 2002; 2
Ding, Yang, Yan, Chen, Desai, Wynshaw-Boris, Shen (bib8) 1998; 395
Li, Ning, Duncan (bib21) 2000; 14
Dinsmore, Ratliff, Deacon, Pakzaban, Jacoby, Galpern, Isacson (bib9) 1996; 5
Isacson, Bjorklund, Schumacher (bib14) 2003; 53
Wilson, Edlund (bib42) 2001; 4
Rhinn, Brand (bib30) 2001; 11
Wrana (bib43) 2000; 100
Bianco, Adkins, Wechselberger, Seno, Normanno, De Luca, Sun, Khan, Kenney, Ebert, Williams, Sanicola, Salomon (bib2) 2002; 22
Deacon, Dinsmore, Costantini, Ratliff, Isacson (bib7) 1998; 149
Sirard, de la Pompa, Elia, Itie, Mirtsos, Cheung, Hahn, Wakeham, Schwartz, Kern, Rossant, Mak (bib34) 1998; 12
Le Belle, Svendsen (bib18) 2002; 16
Evans, Kaufman (bib10) 1981; 292
Munoz-Sanjuan, Brivanlou (bib25) 2001; 237
Tiedemann, Asashima, Grunz, Knochel (bib36) 2001; 43
Kimura, Shen, Takeda, Aizawa, Matsuo (bib17) 2001; 235
Martin (bib22) 1981; 78
Barberi, Klivenyi, Calingasan, Lee, Kawamata, Loonam, Perrier, Bruses, Rubio, Topf, Tabar, Harrison, Beal, Moore, Studer (bib1) 2003; 21
Minchiotti, Parisi, Liguori, D'Andrea, Persico (bib24) 2002; 287
Howell, Itoh, Pierreux, Valgeirsdottir, Itoh, ten Dijke, Hill (bib13) 1999; 214
Weinstein, Yang, Deng (bib39) 2000; 11
Harland (bib11) 2000; 10
Persico, Liguori, Parisi, D'Andrea, Salomon, Minchiotti (bib29) 2001; 1552
Bjorklund, Sanchez-Pernaute, Chung, Andersson, Chen, McNaught, Brownell, Jenkins, Wahlestedt, Kim, Isacson (bib3) 2002; 99
LeSueur, Graff (bib20) 1999; 126
Munoz-Sanjuan, Brivanlou (bib26) 2002; 3
Chung, Sonntag, Andersson, Bjorklund, Park, Kim, Kang, Isacson, Kim (bib5) 2002; 16
Lee, Lumelsky, Studer, Auerbach, McKay (bib19) 2000; 18
Wilson (10.1016/j.mcn.2004.06.003_bib42) 2001; 4
Wrana (10.1016/j.mcn.2004.06.003_bib43) 2000; 100
Minchiotti (10.1016/j.mcn.2004.06.003_bib24) 2002; 287
Whitman (10.1016/j.mcn.2004.06.003_bib40) 2001; 1
Dinsmore (10.1016/j.mcn.2004.06.003_bib9) 1996; 5
Sirard (10.1016/j.mcn.2004.06.003_bib34) 1998; 12
Chung (10.1016/j.mcn.2004.06.003_bib5) 2002; 16
Kim (10.1016/j.mcn.2004.06.003_bib16) 2002; 418
Weissman (10.1016/j.mcn.2004.06.003_bib38) 2000; 287
Kimura (10.1016/j.mcn.2004.06.003_bib17) 2001; 235
Wilkinson (10.1016/j.mcn.2004.06.003_bib41) 1990; 343
Soudais (10.1016/j.mcn.2004.06.003_bib35) 1995; 121
Tiedemann (10.1016/j.mcn.2004.06.003_bib36) 2001; 43
Munoz-Sanjuan (10.1016/j.mcn.2004.06.003_bib25) 2001; 237
Le Belle (10.1016/j.mcn.2004.06.003_bib18) 2002; 16
Deacon (10.1016/j.mcn.2004.06.003_bib7) 1998; 149
Barberi (10.1016/j.mcn.2004.06.003_bib1) 2003; 21
Evans (10.1016/j.mcn.2004.06.003_bib10) 1981; 292
Bianco (10.1016/j.mcn.2004.06.003_bib2) 2002; 22
Massague (10.1016/j.mcn.2004.06.003_bib23) 2000; 14
Oxburgh (10.1016/j.mcn.2004.06.003_bib28) 2002; 112
Ding (10.1016/j.mcn.2004.06.003_bib8) 1998; 395
Martin (10.1016/j.mcn.2004.06.003_bib22) 1981; 78
Rhinn (10.1016/j.mcn.2004.06.003_bib30) 2001; 11
Shen (10.1016/j.mcn.2004.06.003_bib33) 2000; 16
Kawasaki (10.1016/j.mcn.2004.06.003_bib15) 2000; 28
Liguori (10.1016/j.mcn.2004.06.003_bib46) 2003; 264
Munoz-Sanjuan (10.1016/j.mcn.2004.06.003_bib26) 2002; 3
Yan (10.1016/j.mcn.2004.06.003_bib44) 2002; 22
LeSueur (10.1016/j.mcn.2004.06.003_bib20) 1999; 126
Yang (10.1016/j.mcn.2004.06.003_bib45) 1998; 95
Cai (10.1016/j.mcn.2004.06.003_bib4) 2002; 2
Isacson (10.1016/j.mcn.2004.06.003_bib14) 2003; 53
Li (10.1016/j.mcn.2004.06.003_bib21) 2000; 14
Howell (10.1016/j.mcn.2004.06.003_bib13) 1999; 214
Hooper (10.1016/j.mcn.2004.06.003_bib12) 1987; 326
Daley (10.1016/j.mcn.2004.06.003_bib6) 2002; 12
Schier (10.1016/j.mcn.2004.06.003_bib32) 2001; 45
Rossi (10.1016/j.mcn.2004.06.003_bib31) 2002; 3
Nagy (10.1016/j.mcn.2004.06.003_bib27) 1993; 90
Weinstein (10.1016/j.mcn.2004.06.003_bib39) 2000; 11
Harland (10.1016/j.mcn.2004.06.003_bib11) 2000; 10
Bjorklund (10.1016/j.mcn.2004.06.003_bib3) 2002; 99
Lee (10.1016/j.mcn.2004.06.003_bib19) 2000; 18
Persico (10.1016/j.mcn.2004.06.003_bib29) 2001; 1552
Tropepe (10.1016/j.mcn.2004.06.003_bib37) 2001; 30
References_xml – volume: 237
  start-page: 1
  year: 2001
  end-page: 17
  ident: bib25
  article-title: Early posterior/ventral fate specification in the vertebrate embryo
  publication-title: Dev. Biol.
  contributor:
    fullname: Brivanlou
– volume: 21
  start-page: 1200
  year: 2003
  end-page: 1207
  ident: bib1
  article-title: Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Studer
– volume: 418
  start-page: 50
  year: 2002
  end-page: 56
  ident: bib16
  article-title: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
  publication-title: Nature
  contributor:
    fullname: McKay
– volume: 14
  start-page: 464
  year: 2000
  end-page: 474
  ident: bib21
  article-title: Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
  publication-title: Genes Dev.
  contributor:
    fullname: Duncan
– volume: 126
  start-page: 137
  year: 1999
  end-page: 146
  ident: bib20
  article-title: Spemann organizer activity of Smad10
  publication-title: Development
  contributor:
    fullname: Graff
– volume: 287
  start-page: 33
  year: 2002
  end-page: 37
  ident: bib24
  article-title: Role of the EGF–CFC gene cripto in cell differentiation and embryo development
  publication-title: Gene
  contributor:
    fullname: Persico
– volume: 121
  start-page: 3877
  year: 1995
  end-page: 3888
  ident: bib35
  article-title: Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro
  publication-title: Development
  contributor:
    fullname: Wilson
– volume: 149
  start-page: 28
  year: 1998
  end-page: 41
  ident: bib7
  article-title: Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation
  publication-title: Exp. Neurol.
  contributor:
    fullname: Isacson
– volume: 43
  start-page: 469
  year: 2001
  end-page: 502
  ident: bib36
  article-title: Pluripotent cells (stem cells) and their determination and differentiation in early vertebrate embryogenesis
  publication-title: Dev. Growth Differ.
  contributor:
    fullname: Knochel
– volume: 292
  start-page: 154
  year: 1981
  end-page: 156
  ident: bib10
  article-title: Establishment in culture of pluripotential cells from mouse embryos
  publication-title: Nature
  contributor:
    fullname: Kaufman
– volume: 53
  start-page: S135
  year: 2003
  end-page: S146
  ident: bib14
  article-title: Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells
  publication-title: Ann. Neurol.
  contributor:
    fullname: Schumacher
– volume: 235
  start-page: 12
  year: 2001
  end-page: 32
  ident: bib17
  article-title: Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast
  publication-title: Dev. Biol.
  contributor:
    fullname: Matsuo
– volume: 2
  start-page: 233
  year: 2002
  end-page: 249
  ident: bib4
  article-title: Stem cell and precursor cell therapy
  publication-title: Neuromol. Med.
  contributor:
    fullname: Rao
– volume: 3
  start-page: 271
  year: 2002
  end-page: 280
  ident: bib26
  article-title: Neural induction, the default model and embryonic stem cells
  publication-title: Nat. Rev., Neurosci.
  contributor:
    fullname: Brivanlou
– volume: 343
  start-page: 657
  year: 1990
  end-page: 659
  ident: bib41
  article-title: Expression pattern of the mouse T gene and its role in mesoderm formation
  publication-title: Nature
  contributor:
    fullname: Herrmann
– volume: 16
  start-page: 389
  year: 2002
  end-page: 401
  ident: bib18
  article-title: Stem cells for neurodegenerative disorders: where can we go from here?
  publication-title: BioDrugs
  contributor:
    fullname: Svendsen
– volume: 28
  start-page: 31
  year: 2000
  end-page: 40
  ident: bib15
  article-title: Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
  publication-title: Neuron
  contributor:
    fullname: Sasai
– volume: 45
  start-page: 289
  year: 2001
  end-page: 297
  ident: bib32
  article-title: Nodal signaling and the zebrafish organizer
  publication-title: Int. J. Dev. Biol.
  contributor:
    fullname: Talbot
– volume: 287
  start-page: 1442
  year: 2000
  end-page: 1446
  ident: bib38
  article-title: Translating stem and progenitor cell biology to the clinic: barriers and opportunities
  publication-title: Science
  contributor:
    fullname: Weissman
– volume: 16
  start-page: 1829
  year: 2002
  end-page: 1838
  ident: bib5
  article-title: Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
  publication-title: Eur. J. Neurosci.
  contributor:
    fullname: Kim
– volume: 12
  start-page: 107
  year: 1998
  end-page: 119
  ident: bib34
  article-title: The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
  publication-title: Genes Dev.
  contributor:
    fullname: Mak
– volume: 18
  start-page: 675
  year: 2000
  end-page: 679
  ident: bib19
  article-title: Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: McKay
– volume: 95
  start-page: 3667
  year: 1998
  end-page: 3672
  ident: bib45
  article-title: The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Deng
– volume: 395
  start-page: 702
  year: 1998
  end-page: 707
  ident: bib8
  article-title: Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo
  publication-title: Nature
  contributor:
    fullname: Shen
– volume: 14
  start-page: 627
  year: 2000
  end-page: 644
  ident: bib23
  article-title: Controlling TGF-beta signaling
  publication-title: Genes Dev.
  contributor:
    fullname: Chen
– volume: 90
  start-page: 8424
  year: 1993
  end-page: 8428
  ident: bib27
  article-title: Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Roder
– volume: 78
  start-page: 7634
  year: 1981
  end-page: 7638
  ident: bib22
  article-title: Isolation of a pleuripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Martin
– volume: 16
  start-page: 303
  year: 2000
  end-page: 309
  ident: bib33
  article-title: The EGF–CFC gene family in vertebrate development
  publication-title: Trends Genet.
  contributor:
    fullname: Schier
– volume: 4
  start-page: 1161
  year: 2001
  end-page: 1168
  ident: bib42
  article-title: Neural induction: toward a unifying mechanism
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Edlund
– volume: 112
  start-page: 207
  year: 2002
  end-page: 211
  ident: bib28
  article-title: Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney
  publication-title: Mech. Dev.
  contributor:
    fullname: Robertson
– volume: 10
  start-page: 357
  year: 2000
  end-page: 362
  ident: bib11
  article-title: Neural induction
  publication-title: Curr. Opin. Genet. Dev.
  contributor:
    fullname: Harland
– volume: 30
  start-page: 65
  year: 2001
  end-page: 78
  ident: bib37
  article-title: Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
  publication-title: Neuron
  contributor:
    fullname: van der Kooy
– volume: 11
  start-page: 34
  year: 2001
  end-page: 42
  ident: bib30
  article-title: The midbrain–hindbrain boundary organizer
  publication-title: Curr. Opin. Neurobiol.
  contributor:
    fullname: Brand
– volume: 12
  start-page: 607
  year: 2002
  end-page: 613
  ident: bib6
  article-title: Prospects for stem cell therapeutics: myths and medicines
  publication-title: Curr. Opin. Genet. Dev.
  contributor:
    fullname: Daley
– volume: 22
  start-page: 2586
  year: 2002
  end-page: 2597
  ident: bib2
  article-title: Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial cells
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Salomon
– volume: 100
  start-page: 189
  year: 2000
  end-page: 192
  ident: bib43
  article-title: Regulation of Smad activity
  publication-title: Cell
  contributor:
    fullname: Wrana
– volume: 22
  start-page: 4439
  year: 2002
  end-page: 4449
  ident: bib44
  article-title: Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Shen
– volume: 5
  start-page: 131
  year: 1996
  end-page: 143
  ident: bib9
  article-title: Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation
  publication-title: Cell Transplant.
  contributor:
    fullname: Isacson
– volume: 99
  start-page: 2344
  year: 2002
  end-page: 2349
  ident: bib3
  article-title: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Isacson
– volume: 264
  start-page: 537
  year: 2003
  end-page: 549
  ident: bib46
  article-title: Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak
  publication-title: Dev. Biol.
  contributor:
    fullname: Persico
– volume: 1
  start-page: 605
  year: 2001
  end-page: 617
  ident: bib40
  article-title: Nodal signaling in early vertebrate embryos: themes and variations
  publication-title: Dev. Cell
  contributor:
    fullname: Whitman
– volume: 1552
  start-page: 87
  year: 2001
  end-page: 93
  ident: bib29
  article-title: Cripto in tumors and embryo development
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Minchiotti
– volume: 326
  start-page: 292
  year: 1987
  end-page: 295
  ident: bib12
  article-title: HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
  publication-title: Nature
  contributor:
    fullname: Monk
– volume: 3
  start-page: 401
  year: 2002
  end-page: 409
  ident: bib31
  article-title: Opinion: neural stem cell therapy for neurological diseases: dreams and reality
  publication-title: Nat. Rev., Neurosci.
  contributor:
    fullname: Cattaneo
– volume: 11
  start-page: 49
  year: 2000
  end-page: 58
  ident: bib39
  article-title: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
  publication-title: Cytokine Growth Factor Rev.
  contributor:
    fullname: Deng
– volume: 214
  start-page: 354
  year: 1999
  end-page: 369
  ident: bib13
  article-title:
  publication-title: Dev. Biol.
  contributor:
    fullname: Hill
– volume: 90
  start-page: 8424
  year: 1993
  ident: 10.1016/j.mcn.2004.06.003_bib27
  article-title: Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.90.18.8424
  contributor:
    fullname: Nagy
– volume: 235
  start-page: 12
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib17
  article-title: Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.2001.0289
  contributor:
    fullname: Kimura
– volume: 14
  start-page: 627
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib23
  article-title: Controlling TGF-beta signaling
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.6.627
  contributor:
    fullname: Massague
– volume: 287
  start-page: 1442
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib38
  article-title: Translating stem and progenitor cell biology to the clinic: barriers and opportunities
  publication-title: Science
  doi: 10.1126/science.287.5457.1442
  contributor:
    fullname: Weissman
– volume: 292
  start-page: 154
  year: 1981
  ident: 10.1016/j.mcn.2004.06.003_bib10
  article-title: Establishment in culture of pluripotential cells from mouse embryos
  publication-title: Nature
  doi: 10.1038/292154a0
  contributor:
    fullname: Evans
– volume: 1552
  start-page: 87
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib29
  article-title: Cripto in tumors and embryo development
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Persico
– volume: 11
  start-page: 34
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib30
  article-title: The midbrain–hindbrain boundary organizer
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/S0959-4388(00)00171-9
  contributor:
    fullname: Rhinn
– volume: 4
  start-page: 1161
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib42
  article-title: Neural induction: toward a unifying mechanism
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn747
  contributor:
    fullname: Wilson
– volume: 100
  start-page: 189
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib43
  article-title: Regulation of Smad activity
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81556-1
  contributor:
    fullname: Wrana
– volume: 1
  start-page: 605
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib40
  article-title: Nodal signaling in early vertebrate embryos: themes and variations
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(01)00076-4
  contributor:
    fullname: Whitman
– volume: 22
  start-page: 4439
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib44
  article-title: Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.22.13.4439-4449.2002
  contributor:
    fullname: Yan
– volume: 3
  start-page: 271
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib26
  article-title: Neural induction, the default model and embryonic stem cells
  publication-title: Nat. Rev., Neurosci.
  doi: 10.1038/nrn786
  contributor:
    fullname: Munoz-Sanjuan
– volume: 16
  start-page: 389
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib18
  article-title: Stem cells for neurodegenerative disorders: where can we go from here?
  publication-title: BioDrugs
  doi: 10.2165/00063030-200216060-00001
  contributor:
    fullname: Le Belle
– volume: 214
  start-page: 354
  year: 1999
  ident: 10.1016/j.mcn.2004.06.003_bib13
  article-title: Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.1999.9430
  contributor:
    fullname: Howell
– volume: 395
  start-page: 702
  year: 1998
  ident: 10.1016/j.mcn.2004.06.003_bib8
  article-title: Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo
  publication-title: Nature
  doi: 10.1038/27215
  contributor:
    fullname: Ding
– volume: 10
  start-page: 357
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib11
  article-title: Neural induction
  publication-title: Curr. Opin. Genet. Dev.
  doi: 10.1016/S0959-437X(00)00096-4
  contributor:
    fullname: Harland
– volume: 3
  start-page: 401
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib31
  article-title: Opinion: neural stem cell therapy for neurological diseases: dreams and reality
  publication-title: Nat. Rev., Neurosci.
  doi: 10.1038/nrn809
  contributor:
    fullname: Rossi
– volume: 99
  start-page: 2344
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib3
  article-title: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.022438099
  contributor:
    fullname: Bjorklund
– volume: 5
  start-page: 131
  year: 1996
  ident: 10.1016/j.mcn.2004.06.003_bib9
  article-title: Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation
  publication-title: Cell Transplant.
  doi: 10.1016/0963-6897(95)02040-3
  contributor:
    fullname: Dinsmore
– volume: 126
  start-page: 137
  year: 1999
  ident: 10.1016/j.mcn.2004.06.003_bib20
  article-title: Spemann organizer activity of Smad10
  publication-title: Development
  doi: 10.1242/dev.126.1.137
  contributor:
    fullname: LeSueur
– volume: 78
  start-page: 7634
  year: 1981
  ident: 10.1016/j.mcn.2004.06.003_bib22
  article-title: Isolation of a pleuripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.78.12.7634
  contributor:
    fullname: Martin
– volume: 121
  start-page: 3877
  year: 1995
  ident: 10.1016/j.mcn.2004.06.003_bib35
  article-title: Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro
  publication-title: Development
  doi: 10.1242/dev.121.11.3877
  contributor:
    fullname: Soudais
– volume: 418
  start-page: 50
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib16
  article-title: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
  publication-title: Nature
  doi: 10.1038/nature00900
  contributor:
    fullname: Kim
– volume: 343
  start-page: 657
  year: 1990
  ident: 10.1016/j.mcn.2004.06.003_bib41
  article-title: Expression pattern of the mouse T gene and its role in mesoderm formation
  publication-title: Nature
  doi: 10.1038/343657a0
  contributor:
    fullname: Wilkinson
– volume: 21
  start-page: 1200
  year: 2003
  ident: 10.1016/j.mcn.2004.06.003_bib1
  article-title: Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt870
  contributor:
    fullname: Barberi
– volume: 237
  start-page: 1
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib25
  article-title: Early posterior/ventral fate specification in the vertebrate embryo
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.2001.0350
  contributor:
    fullname: Munoz-Sanjuan
– volume: 53
  start-page: S135
  issue: Suppl. 3
  year: 2003
  ident: 10.1016/j.mcn.2004.06.003_bib14
  article-title: Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.10482
  contributor:
    fullname: Isacson
– volume: 14
  start-page: 464
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib21
  article-title: Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.4.464
  contributor:
    fullname: Li
– volume: 264
  start-page: 537
  year: 2003
  ident: 10.1016/j.mcn.2004.06.003_bib46
  article-title: Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2003.08.023
  contributor:
    fullname: Liguori
– volume: 12
  start-page: 607
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib6
  article-title: Prospects for stem cell therapeutics: myths and medicines
  publication-title: Curr. Opin. Genet. Dev.
  doi: 10.1016/S0959-437X(02)00346-5
  contributor:
    fullname: Daley
– volume: 43
  start-page: 469
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib36
  article-title: Pluripotent cells (stem cells) and their determination and differentiation in early vertebrate embryogenesis
  publication-title: Dev. Growth Differ.
  doi: 10.1046/j.1440-169X.2001.00599.x
  contributor:
    fullname: Tiedemann
– volume: 112
  start-page: 207
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib28
  article-title: Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney
  publication-title: Mech. Dev.
  doi: 10.1016/S0925-4773(01)00648-7
  contributor:
    fullname: Oxburgh
– volume: 12
  start-page: 107
  year: 1998
  ident: 10.1016/j.mcn.2004.06.003_bib34
  article-title: The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
  publication-title: Genes Dev.
  doi: 10.1101/gad.12.1.107
  contributor:
    fullname: Sirard
– volume: 30
  start-page: 65
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib37
  article-title: Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
  publication-title: Neuron
  doi: 10.1016/S0896-6273(01)00263-X
  contributor:
    fullname: Tropepe
– volume: 16
  start-page: 1829
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib5
  article-title: Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
  publication-title: Eur. J. Neurosci.
  doi: 10.1046/j.1460-9568.2002.02255.x
  contributor:
    fullname: Chung
– volume: 287
  start-page: 33
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib24
  article-title: Role of the EGF–CFC gene cripto in cell differentiation and embryo development
  publication-title: Gene
  doi: 10.1016/S0378-1119(01)00892-7
  contributor:
    fullname: Minchiotti
– volume: 18
  start-page: 675
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib19
  article-title: Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/76536
  contributor:
    fullname: Lee
– volume: 11
  start-page: 49
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib39
  article-title: Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/S1359-6101(99)00028-3
  contributor:
    fullname: Weinstein
– volume: 16
  start-page: 303
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib33
  article-title: The EGF–CFC gene family in vertebrate development
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(00)02006-0
  contributor:
    fullname: Shen
– volume: 95
  start-page: 3667
  year: 1998
  ident: 10.1016/j.mcn.2004.06.003_bib45
  article-title: The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.95.7.3667
  contributor:
    fullname: Yang
– volume: 45
  start-page: 289
  year: 2001
  ident: 10.1016/j.mcn.2004.06.003_bib32
  article-title: Nodal signaling and the zebrafish organizer
  publication-title: Int. J. Dev. Biol.
  contributor:
    fullname: Schier
– volume: 149
  start-page: 28
  year: 1998
  ident: 10.1016/j.mcn.2004.06.003_bib7
  article-title: Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation
  publication-title: Exp. Neurol.
  doi: 10.1006/exnr.1997.6674
  contributor:
    fullname: Deacon
– volume: 2
  start-page: 233
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib4
  article-title: Stem cell and precursor cell therapy
  publication-title: Neuromol. Med.
  doi: 10.1385/NMM:2:3:233
  contributor:
    fullname: Cai
– volume: 28
  start-page: 31
  year: 2000
  ident: 10.1016/j.mcn.2004.06.003_bib15
  article-title: Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)00083-0
  contributor:
    fullname: Kawasaki
– volume: 326
  start-page: 292
  year: 1987
  ident: 10.1016/j.mcn.2004.06.003_bib12
  article-title: HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
  publication-title: Nature
  doi: 10.1038/326292a0
  contributor:
    fullname: Hooper
– volume: 22
  start-page: 2586
  year: 2002
  ident: 10.1016/j.mcn.2004.06.003_bib2
  article-title: Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial cells
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.22.8.2586-2597.2002
  contributor:
    fullname: Bianco
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Snippet Activation of transforming growth factor-β (TGF-β) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural fates....
Activation of transforming growth factor-beta (TGF-beta) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural...
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SubjectTerms Animals
Brain - cytology
Brain - embryology
Brain - metabolism
Cell Differentiation - physiology
Cell Lineage - physiology
DNA-Binding Proteins - genetics
Dopamine - metabolism
Ectoderm - cytology
Ectoderm - metabolism
Embryonic Induction - physiology
Epidermal Growth Factor - genetics
Germ Layers - cytology
Germ Layers - metabolism
Membrane Glycoproteins - genetics
Mesoderm - cytology
Mesoderm - metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasm Proteins - genetics
Neurons - cytology
Neurons - metabolism
Phenotype
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Serotonin - metabolism
Signal Transduction - physiology
Smad4 Protein
Stem Cell Transplantation - methods
Trans-Activators - genetics
Transforming Growth Factor beta - metabolism
Title Context-dependent neuronal differentiation and germ layer induction of Smad4 −/− and Cripto −/− embryonic stem cells
URI https://dx.doi.org/10.1016/j.mcn.2004.06.003
https://www.ncbi.nlm.nih.gov/pubmed/15737733
https://search.proquest.com/docview/67472877
Volume 28
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