A redox proteomics approach to investigate the mode of action of nanomaterials

• Published in: Toxicology and applied pharmacology Vol. 299; pp. 24 - 29
• Main Authors: Riebeling, Christian, Wiemann, Martin, Schnekenburger, Jürgen, Kuhlbusch, Thomas A.J., Wohlleben, Wendel, Luch, Andreas, Haase, Andrea
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2016
• Subjects: 60 APPLIED LIFE SCIENCES; Acellular tests; ANTIOXIDANTS; BIOLOGICAL STRESS; CARBONYLATION; Chemical Engineering - methods; ELECTRON SPIN RESONANCE; FLUORESCENCE; IN VITRO; IN VIVO; NANOMATERIALS; Nanostructures - chemistry; Nanostructures - toxicity; OXIDATION; Oxidation-Reduction; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Protein carbonylation; PROTEINS; Proteomics; Proteomics - methods; Reactive Oxygen Species - metabolism; READOUT SYSTEMS; SCREENING; Toxicity mechanisms; Toxicity mechanisms; Oxidative stress; Acellular tests; Protein carbonylation; Proteomics

Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In paralle...