A redox proteomics approach to investigate the mode of action of nanomaterials
Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In paralle...
Saved in:
Published in | Toxicology and applied pharmacology Vol. 299; pp. 24 - 29 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
15.05.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive research efforts are targeted to understanding modes of action of ENMs, which may also support the development of new predictive assays. Oxidative stress is a widely accepted paradigm associated with different adverse outcomes of ENMs. It has frequently been identified in in vitro and in vivo studies and different assays have been developed for this purpose. Fluorescent dye based read-outs are most frequently used for cell testing in vitro but may be limited due to possible interference of the ENMs. Recently, other assays have been put forward such as acellular determination of ROS production potential using methods like electron spin resonance, antioxidant quantification or the use of specific sensors. In addition, Omics based approaches have gained increasing attention. In particular, redox proteomics can combine the assessment of oxidative stress with the advantage of getting more detailed mechanistic information. Here we propose a comprehensive testing strategy for assessing the oxidative stress potential of ENMs, which combines acellular methods and fast in vitro screening approaches, as well as a more involved detailed redox proteomics approach. This allows for screening and prioritization in a first tier and, if required, also for unraveling mechanistic details down to compromised signaling pathways.
•Oxidative stress is a general paradigm for nanomaterial hazard mechanism of action.•Reactive oxygen species generation can be predicted using acellular assays.•Cellular assays based on fluorescence suffer from interference by nanomaterials.•Protein carbonylation is an irreversible and predictive mark of oxidative stress.•Proteomics of carbonylation indicates affected pathways and mechanism of action. |
---|---|
AbstractList | Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive research efforts are targeted to understanding modes of action of ENMs, which may also support the development of new predictive assays. Oxidative stress is a widely accepted paradigm associated with different adverse outcomes of ENMs. It has frequently been identified in in vitro and in vivo studies and different assays have been developed for this purpose. Fluorescent dye based read-outs are most frequently used for cell testing in vitro but may be limited due to possible interference of the ENMs. Recently, other assays have been put forward such as acellular determination of ROS production potential using methods like electron spin resonance, antioxidant quantification or the use of specific sensors. In addition, Omics based approaches have gained increasing attention. In particular, redox proteomics can combine the assessment of oxidative stress with the advantage of getting more detailed mechanistic information. Here we propose a comprehensive testing strategy for assessing the oxidative stress potential of ENMs, which combines acellular methods and fast in vitro screening approaches, as well as a more involved detailed redox proteomics approach. This allows for screening and prioritization in a first tier and, if required, also for unraveling mechanistic details down to compromised signaling pathways.
•Oxidative stress is a general paradigm for nanomaterial hazard mechanism of action.•Reactive oxygen species generation can be predicted using acellular assays.•Cellular assays based on fluorescence suffer from interference by nanomaterials.•Protein carbonylation is an irreversible and predictive mark of oxidative stress.•Proteomics of carbonylation indicates affected pathways and mechanism of action. Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive research efforts are targeted to understanding modes of action of ENMs, which may also support the development of new predictive assays. Oxidative stress is a widely accepted paradigm associated with different adverse outcomes of ENMs. It has frequently been identified in in vitro and in vivo studies and different assays have been developed for this purpose. Fluorescent dye based read-outs are most frequently used for cell testing in vitro but may be limited due to possible interference of the ENMs. Recently, other assays have been put forward such as acellular determination of ROS production potential using methods like electron spin resonance, antioxidant quantification or the use of specific sensors. In addition, Omics based approaches have gained increasing attention. In particular, redox proteomics can combine the assessment of oxidative stress with the advantage of getting more detailed mechanistic information. Here we propose a comprehensive testing strategy for assessing the oxidative stress potential of ENMs, which combines acellular methods and fast in vitro screening approaches, as well as a more involved detailed redox proteomics approach. This allows for screening and prioritization in a first tier and, if required, also for unraveling mechanistic details down to compromised signaling pathways. Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable for high throughput screening and prioritization are urgently needed to ensure a fast and effective development of safe products. In parallel, extensive research efforts are targeted to understanding modes of action of ENMs, which may also support the development of new predictive assays. Oxidative stress is a widely accepted paradigm associated with different adverse outcomes of ENMs. It has frequently been identified in in vitro and in vivo studies and different assays have been developed for this purpose. Fluorescent dye based read-outs are most frequently used for cell testing in vitro but may be limited due to possible interference of the ENMs. Recently, other assays have been put forward such as acellular determination of ROS production potential using methods like electron spin resonance, antioxidant quantification or the use of specific sensors. In addition, Omics based approaches have gained increasing attention. In particular, redox proteomics can combine the assessment of oxidative stress with the advantage of getting more detailed mechanistic information. Here we propose a comprehensive testing strategy for assessing the oxidative stress potential of ENMs, which combines acellular methods and fast in vitro screening approaches, as well as a more involved detailed redox proteomics approach. This allows for screening and prioritization in a first tier and, if required, also for unraveling mechanistic details down to compromised signaling pathways. - Highlights: • Oxidative stress is a general paradigm for nanomaterial hazard mechanism of action. • Reactive oxygen species generation can be predicted using acellular assays. • Cellular assays based on fluorescence suffer from interference by nanomaterials. • Protein carbonylation is an irreversible and predictive mark of oxidative stress. • Proteomics of carbonylation indicates affected pathways and mechanism of action. |
Author | Schnekenburger, Jürgen Haase, Andrea Riebeling, Christian Wohlleben, Wendel Luch, Andreas Wiemann, Martin Kuhlbusch, Thomas A.J. |
Author_xml | – sequence: 1 givenname: Christian surname: Riebeling fullname: Riebeling, Christian organization: German Federal Institute for Risk Assessment (BfR), Department of Chemicals and Product Safety, Berlin, Germany – sequence: 2 givenname: Martin surname: Wiemann fullname: Wiemann, Martin organization: IBE R&D gGmbH, Institute for Lung Health, Münster, Germany – sequence: 3 givenname: Jürgen surname: Schnekenburger fullname: Schnekenburger, Jürgen organization: Biomedical Technology Center, Westfälische Wilhelms-University, Münster, Germany – sequence: 4 givenname: Thomas A.J. surname: Kuhlbusch fullname: Kuhlbusch, Thomas A.J. organization: Institute of Energy and Environmental Technology (IUTA) e.V., Air Quality & Sustainable Nanotechnology, Duisburg, Germany – sequence: 5 givenname: Wendel surname: Wohlleben fullname: Wohlleben, Wendel organization: BASF SE, Material Physics, Ludwigshafen, Germany – sequence: 6 givenname: Andreas surname: Luch fullname: Luch, Andreas organization: German Federal Institute for Risk Assessment (BfR), Department of Chemicals and Product Safety, Berlin, Germany – sequence: 7 givenname: Andrea surname: Haase fullname: Haase, Andrea email: andrea.haase@bfr.bund.de organization: German Federal Institute for Risk Assessment (BfR), Department of Chemicals and Product Safety, Berlin, Germany |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26827820$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/22687943$$D View this record in Osti.gov |
BookMark | eNp9UMFqGzEQFSWhdtz-QA9B0Esu64yk1e4KegkmbQqhuaTQm5C1s7WMV3Il2SR_Hy1OegwMzAi9efPeuyBnPngk5AuDJQPWXG-X2Zj9kpd5CayU-kDmDFRTgRDijMwBalYBdH9m5CKlLQCoumYfyYw3HW87DnPy64ZG7MMT3ceQMYzOJmr25WHshuZAnT9iyu6vyUjzBukYeqRhoMZmF_w0eePDWL6jM7v0iZwPpeHn174gv7_fPq7uqvuHHz9XN_eVrVmbq7WQhskaVV8LAT1nQrVS8EE0DayVUKqRXA5tZ5U1kg-yNWbgPe_QopWgBrEgX0-8oYjTybqMdmOD92iz5sVeqwrzglydUMXPv0PxoUeXLO52xmM4JM3aTvKalaMFyk9QG0NKEQe9j2408Vkz0FPaequntPWUtgZWSpWly1f-w3rE_v_KW7wF8O0EwJLF0WGcpKK32Ls4Ke2De4__BbzEkTc |
CitedBy_id | crossref_primary_10_1016_j_impact_2024_100521 crossref_primary_10_1039_C7EN00346C crossref_primary_10_1016_j_toxlet_2018_06_003 crossref_primary_10_1093_mutage_gew056 crossref_primary_10_1016_j_impact_2017_08_002 crossref_primary_10_1016_j_impact_2017_10_007 crossref_primary_10_1016_j_yrtph_2016_05_037 crossref_primary_10_1002_etc_4145 crossref_primary_10_1016_j_envpol_2017_03_033 crossref_primary_10_1088_1742_6596_838_1_012033 crossref_primary_10_3390_nano13030472 crossref_primary_10_1080_17435390_2017_1415388 crossref_primary_10_1016_j_impact_2017_09_002 crossref_primary_10_1016_j_mrrev_2016_03_002 crossref_primary_10_3389_ftox_2021_653386 crossref_primary_10_1016_j_impact_2020_100234 crossref_primary_10_1016_j_mrrev_2016_11_001 |
Cites_doi | 10.1126/science.1114397 10.1016/j.taap.2010.03.009 10.1016/j.freeradbiomed.2007.06.026 10.1016/j.bbapap.2004.08.007 10.1016/j.nantod.2013.01.001 10.1016/S1471-4914(03)00031-5 10.1007/s12013-012-9367-9 10.1016/j.redox.2015.08.016 10.1111/j.1582-4934.2006.tb00407.x 10.1093/toxsci/kfs003 10.1016/j.aquatox.2009.09.004 10.1080/10408440903120975 10.1016/j.tox.2008.12.023 10.1021/acs.est.5b02967 10.1002/mas.21374 10.1002/smll.201201995 10.1038/sj.cdd.4401338 10.1039/c3pp50182e 10.1016/j.bbapap.2014.03.007 10.1016/j.jfda.2014.01.004 10.1039/b303928p 10.1021/pr1002609 10.1016/j.nantod.2011.03.002 10.14336/AD.2013.0400276 10.1136/oemed-2014-102303 10.1016/j.biomaterials.2014.08.031 10.3109/08958378.2015.1026620 10.1016/j.ceb.2014.09.010 10.1016/j.talanta.2013.07.077 10.1186/s12989-015-0108-2 10.3390/biom5031399 10.1089/ars.2009.2805 10.1007/s11051-015-3181-4 10.1021/acs.est.5b00997 10.1016/j.freeradbiomed.2015.03.022 10.1089/ars.2012.4595 10.1038/sj.bjp.0705776 10.1046/j.1523-1747.2000.00865.x 10.1016/j.tiv.2013.09.009 10.1093/oxfordjournals.jbchem.a021306 10.3390/ijerph120910806 10.1080/15287390903489422 10.1016/j.tox.2013.08.011 10.1080/10715760600918142 10.1016/j.toxlet.2015.09.025 10.1016/j.chemosphere.2014.01.054 10.1016/S0076-6879(94)33040-9 10.1038/oby.2011.115 10.1038/nnano.2012.207 10.2174/1875397301105010001 10.1021/nn200163w 10.1016/j.cbi.2014.06.020 10.1016/j.toxlet.2015.05.021 10.3109/17435390.2013.829590 10.1016/j.tibs.2014.02.002 10.1016/j.aquatox.2005.10.011 10.1186/1743-8977-11-4 10.3109/17435390.2015.1019585 10.1016/j.mrgentox.2015.11.011 10.1021/nn4050744 10.1074/jbc.R113.461368 10.1002/mas.21375 10.1021/tx400410s 10.1021/nn9005973 10.1007/s00204-012-0837-z 10.1021/acsnano.5b04661 10.1016/j.carbon.2014.10.009 10.1016/j.taap.2008.09.030 10.1016/j.marenvres.2008.04.002 10.1016/j.biomaterials.2007.02.034 10.3109/15376516.2015.1025347 10.1166/jnn.2015.9032 10.1007/s00204-012-0944-x 10.1089/ars.2011.4109 10.1016/j.mrgentox.2011.09.013 10.1006/abio.1998.2932 10.1007/s11051-013-2167-3 10.1016/j.taap.2009.09.004 |
ContentType | Journal Article |
Copyright | 2016 Copyright © 2016. Published by Elsevier Inc. |
Copyright_xml | – notice: 2016 – notice: Copyright © 2016. Published by Elsevier Inc. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7ST 7U7 C1K SOI OTOTI |
DOI | 10.1016/j.taap.2016.01.019 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Environment Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management Environment Abstracts OSTI.GOV |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Toxicology Abstracts Environment Abstracts Environmental Sciences and Pollution Management |
DatabaseTitleList | MEDLINE Toxicology Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Public Health Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1096-0333 |
EndPage | 29 |
ExternalDocumentID | 22687943 10_1016_j_taap_2016_01_019 26827820 S0041008X16300199 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKC AAIKJ AAKOC AALRI AAMNW AAOAW AAQFI AATCM AAXUO ABFRF ABFYP ABJNI ABLST ABMAC ABYKQ ABZDS ACDAQ ACGFO ACGFS ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLECG BLXMC C45 CS3 DM4 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KCYFY KOM LG5 M33 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SDF SDG SDP SES SPCBC SSJ SSP SSZ T5K TEORI TWZ WH7 ZU3 ~G- AAXKI AKRWK CGR CUY CVF ECM EIF NPM .55 .GJ .HR 29Q 3O- 53G AAQXK AAYXX ABEFU ABFNM ABXDB ACRPL ADFGL ADMUD ADNMO AFFNX AFJKZ AHHHB ASPBG AVWKF AZFZN CAG CITATION COF FEDTE FGOYB G-2 HMT HVGLF HZ~ R2- SEW SPT UHS WUQ X7M XJT XPP Y6R YCJ ZGI ZKB ZMT ZXP ~KM 7ST 7U7 C1K SOI AALMO AAPBV ABPIF ABPTK ABQIS EFJIC OTOTI |
ID | FETCH-LOGICAL-c417t-b35a154e9d4330d21397532f3660b93996525f78c9ca52f57aaf2d28ecec509f3 |
IEDL.DBID | AIKHN |
ISSN | 0041-008X |
IngestDate | Fri May 19 01:41:06 EDT 2023 Fri Oct 25 10:35:34 EDT 2024 Fri Dec 06 05:49:01 EST 2024 Sat Sep 28 08:05:28 EDT 2024 Fri Feb 23 02:29:42 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Toxicity mechanisms Oxidative stress Acellular tests Protein carbonylation Proteomics |
Language | English |
License | Copyright © 2016. Published by Elsevier Inc. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c417t-b35a154e9d4330d21397532f3660b93996525f78c9ca52f57aaf2d28ecec509f3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 26827820 |
PQID | 1785241660 |
PQPubID | 23462 |
PageCount | 6 |
ParticipantIDs | osti_scitechconnect_22687943 proquest_miscellaneous_1785241660 crossref_primary_10_1016_j_taap_2016_01_019 pubmed_primary_26827820 elsevier_sciencedirect_doi_10_1016_j_taap_2016_01_019 |
PublicationCentury | 2000 |
PublicationDate | 2016-05-15 |
PublicationDateYYYYMMDD | 2016-05-15 |
PublicationDate_xml | – month: 05 year: 2016 text: 2016-05-15 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Toxicology and applied pharmacology |
PublicationTitleAlternate | Toxicol Appl Pharmacol |
PublicationYear | 2016 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Dowling, Hoarau, Romeo, O'Halloran, van Pelt, O'Brien, Sheehan (bb0070) 2006; 77 Haase, Rott, Mantion, Graf, Plendl, Thunemann, Meier, Taubert, Luch, Reiser (bb0150) 2012; 126 Papageorgiou, Brown, Schins, Singh, Newson, Davis, Fisher, Ingham, Case (bb0305) 2007; 28 Dalle-Donne, Giustarini, Colombo, Rossi, Milzani (bb0045) 2003; 9 Langmuir, Yang, LeCompte, Durand (bb0220) 1996 OECD, 2012. The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins — part 1: scientific evidence. ENV/JM/MONO(2012)10/PART1. Series on Testing and Assessment. Environment Directorate of the OECD, Paris. Haase, Arlinghaus, Tentschert, Jungnickel, Graf, Mantion, Draude, Galla, Plendl, Goetz, Masic, Meier, Thunemann, Taubert, Luch (bb0145) 2011; 5 Grek, Zhang, Manevich, Townsend, Tew (bb0130) 2013; 288 Huo, Chen, Shi, Bai, Wang, Chang, Chen (bb0195) 2015; 15 Kroll, Pillukat, Hahn, Schnekenburger (bb0215) 2012; 86 Avalos, Haza, Mateo, Morales (bb0010) 2015; 25 Monteiro-Riviere, Inman, Zhang (bb0255) 2009; 234 Davies (bb0050) 2005; 1703 Murray, Kisin, Inman, Young, Muhammed, Burks, Uheida, Tkach, Waltz, Castranova, Fadeel, Kagan, Riviere, Monteiro-Riviere, Shvedova (bb0260) 2013; 67 Doak, Manshian, Jenkins, Singh (bb0065) 2012; 745 Go, Chandler, Jones (bb0120) 2015; 84 Levine, Williams, Stadtman, Shacter (bb0225) 1994; 233 Zhang, Yan, Li, Zhao, Yang, Ji, Gu, Yin, Gao, Nie (bb0410) 2015; 237 Neubauer, Palomaeki, Karisola, Alenius, Kasper (bb0280) 2015; 9 Wardman (bb0400) 2007; 43 Halliwell, Whiteman (bb0155) 2004; 142 Vinken (bb0390) 2013; 312 Madian, Regnier (bb0230) 2010; 9 Wong, Marcocci, Liu, Suzuki (bb0405) 2010; 12 Flaherty, Chandrasekaran, Pena Mdel, Roth, Brenner, Begley, Melendez (bb0105) 2015; 239 Hsieh, Bello, Schmidt, Pal, Stella, Isaacs, Rogers (bb0185) 2013; 9 Rajiv, Jerobin, Saranya, Nainawat, Sharma, Makwana, Gayathri, Bharath, Singh, Kumar, Mukherjee, Chandrasekaran (bb0320) 2015; 1-14 Simmons, Fan, Yeoman, Wakefield, Ramabhadran (bb0350) 2011; 5 Gorlach, Dimova, Petry, Martinez-Ruiz, Hernansanz-Agustin, Rolo, Palmeira, Kietzmann (bb0125) 2015; 6 Øvrevik, Refsnes, Lag, Holme, Schwarze (bb0295) 2015; 5 Ergin, Hariry, Karasu (bb0095) 2013; 4 Shi, Schins, Knaapen, Kuhlbusch, Pitz, Heinrich, Borm (bb0340) 2003; 5 Verano-Braga, Miethling-Graff, Wojdyla, Rogowska-Wrzesinska, Brewer, Erdmann, Kjeldsen (bb0385) 2014; 8 Manshian, Pfeiffer, Pelaz, Heimerl, Gallego, Moller, Del Pino, Himmelreich, Parak, Soenen (bb0240) 2015; 9 Sturla, Boobis, FitzGerald, Hoeng, Kavlock, Schirmer, Whelan, Wilks, Peitsch (bb0370) 2014; 27 Nakamura, Goto (bb0270) 1996; 119 Accessed 06 Nov 2015 Guadagnini, Halamoda Kenzaoui, Walker, Pojana, Magdolenova, Bilanicova, Saunders, Juillerat-Jeanneret, Marcomini, Huk, Dusinska, Fjellsbo, Marano, Boland (bb0140) 2015; 9 Rushton, Jiang, Leonard, Eberly, Castranova, Biswas, Elder, Han, Gelein, Finkelstein, Oberdorster (bb0335) 2010; 73 Groitl, Jakob (bb0135) 2014; 1844 Ching, Chew, Wong, Ip (bb0035) 2009; 95 Stone, Johnston, Schins (bb0365) 2009; 39 Almroth, Sturve, Stephensen, Holth, Forlin (bb0005) 2008; 66 Murray, Kisin, Leonard, Young, Kommineni, Kagan, Castranova, Shvedova (bb0265) 2009; 257 Reczek, Chandel (bb0325) 2015; 33 Feeney, Schoneich (bb0100) 2012; 17 Stan, Memet, Sima, Popescu, Teodorescu, Hermenean, Dinischiotu (bb0360) 2014; 220 Cabiscol, Tamarit, Ros (bb0030) 2014; 33 Dalle-Donne, Aldini, Carini, Colombo, Rossi, Milzani (bb0040) 2006; 10 Emter, Ellis, Natsch (bb0080) 2010; 245 Hankin, Boraschi, Duschl, Lehr, Lichtenbeld (bb0160) 2011; 6 Butterfield, Perluigi, Reed, Muharib, Hughes, Robinson, Sultana (bb0025) 2012; 17 Hu, Culloty, Darmody, Lynch, Davenport, Ramirez-Garcia, Dawson, Lynch, Blasco, Sheehan (bb0190) 2014; 108 Manshian, Moyano, Corthout, Munck, Himmelreich, Rotello, Soenen (bb0235) 2014; 35 Monopoli, Aberg, Salvati, Dawson (bb0250) 2012; 7 Henkler, Tralau, Tentschert, Kneuer, Haase, Platzek, Luch, Gotz (bb0175) 2012; 86 Jensen, Kembouche, Nielsen (bb0205) 2013 England, O'Driscoll, Cotter (bb0090) 2004; 11 He, Liu, Wamer, Yin (bb0170) 2014; 22 Decan, Wu, Williams, Bernatchez, Johnston, Hill, Halappanavar (bb0055) 2016; 796 Plowman, Deb-Choudhury, Grosvenor, Dyer (bb0315) 2013; 12 Robinson, Keshavarzian, Pasco, Frommel, Winship, Holmes (bb0330) 1999; 266 Meng, Xia, George, Nel (bb0245) 2009; 3 Emter, van der Veen, Adamson, Ezendam, van Loveren, Natsch (bb0085) 2013; 27 Nymark, Jensen, Suhonen, Kembouche, Vippola, Kleinjans, Catalan, Norppa, van Delft, Briede (bb0285) 2014; 11 Hoet, Nemery, Napierska (bb0180) 2013; 8 Stadtman (bb0355) 2006; 40 Frohnert, Sinaiko, Serrot, Foncea, Moran, Ikramuddin, Choudry, Bernlohr (bb0110) 2011; 19 Janssen, Strak, Yang, Hellack, Kelly, Kuhlbusch, Harrison, Brunekreef, Cassee, Steenhof, Hoek (bb0200) 2015; 72 Bates, Weber, Abrams, Verma, Fang, Klein, Strickland, Sarnat, Chang, Mulholland, Tolbert, Russell (bb0015) 2015; 49 Kang, Kim, Kim, Woo, Pikhitsa, Cho, Choi (bb0210) 2015; 17 Driessen, Mues, Vennemann, Hellack, Bannuscher, Vimalakanthan, Riebeling, Ossig, Wiemann, Schnekenburger, Kuhlbusch, Renard, Luch, Haase (bb0075) 2015; 12 Butterfield, Gu, Di Domenico, Robinson (bb0020) 2014; 33 Nel, Xia, Madler, Li (bb0275) 2006; 311 Tsuruoka, Matsumoto, Koyama, Akiba, Yanagisawa, Cassee, Saito, Usui, Kobayashi, Porter, Castranova, Endo (bb0380) 2015; 83 Tournebize, Sapin-Minet, Bartosz, Leroy, Boudier (bb0375) 2013; 116 Petersen, Diamond, Kennedy, Goss, Ho, Lead, Hanna, Hartmann, Hund-Rinke, Mader, Manier, Pandard, Salinas, Sayre (bb0310) 2015; 49 Shvedova, Kommineni, Jeffries, Castranova, Tyurina, Tyurin, Serbinova, Fabisiak, Kagan (bb0345) 2000; 114 Fujita, Fukuda, Endoh, Maru, Kato, Nakamura, Shinohara, Uchino, Honda (bb0115) 2015; 27 Hayes, Dinkova-Kostova (bb0165) 2014; 39 Ding, Kisin, Zhao, Bowman, Lu, Jiang, Leonard, Vallyathan, Castranova, Murray, Fadeel, Shvedova (bb0060) 2009; 241 Pal, Hsieh, Khatri, Isaacs, Demokritou, Gaines, Schmidt, Rogers, Bello (bb0300) 2014; 16 Wang, Ai, Zhai, Li, Zhou, Chen (bb0395) 2015; 12 Dalle-Donne (10.1016/j.taap.2016.01.019_bb0040) 2006; 10 Tsuruoka (10.1016/j.taap.2016.01.019_bb0380) 2015; 83 Henkler (10.1016/j.taap.2016.01.019_bb0175) 2012; 86 Vinken (10.1016/j.taap.2016.01.019_bb0390) 2013; 312 Grek (10.1016/j.taap.2016.01.019_bb0130) 2013; 288 Stadtman (10.1016/j.taap.2016.01.019_bb0355) 2006; 40 Shvedova (10.1016/j.taap.2016.01.019_bb0345) 2000; 114 Janssen (10.1016/j.taap.2016.01.019_bb0200) 2015; 72 Wang (10.1016/j.taap.2016.01.019_bb0395) 2015; 12 Petersen (10.1016/j.taap.2016.01.019_bb0310) 2015; 49 Stan (10.1016/j.taap.2016.01.019_bb0360) 2014; 220 Ergin (10.1016/j.taap.2016.01.019_bb0095) 2013; 4 Monteiro-Riviere (10.1016/j.taap.2016.01.019_bb0255) 2009; 234 Rushton (10.1016/j.taap.2016.01.019_bb0335) 2010; 73 Ching (10.1016/j.taap.2016.01.019_bb0035) 2009; 95 Hankin (10.1016/j.taap.2016.01.019_bb0160) 2011; 6 Driessen (10.1016/j.taap.2016.01.019_bb0075) 2015; 12 Hoet (10.1016/j.taap.2016.01.019_bb0180) 2013; 8 Rajiv (10.1016/j.taap.2016.01.019_bb0320) 2015; 1-14 Go (10.1016/j.taap.2016.01.019_bb0120) 2015; 84 Dowling (10.1016/j.taap.2016.01.019_bb0070) 2006; 77 Flaherty (10.1016/j.taap.2016.01.019_bb0105) 2015; 239 Haase (10.1016/j.taap.2016.01.019_bb0145) 2011; 5 Haase (10.1016/j.taap.2016.01.019_bb0150) 2012; 126 Davies (10.1016/j.taap.2016.01.019_bb0050) 2005; 1703 Plowman (10.1016/j.taap.2016.01.019_bb0315) 2013; 12 Doak (10.1016/j.taap.2016.01.019_bb0065) 2012; 745 Kang (10.1016/j.taap.2016.01.019_bb0210) 2015; 17 Manshian (10.1016/j.taap.2016.01.019_bb0235) 2014; 35 10.1016/j.taap.2016.01.019_bb0290 Emter (10.1016/j.taap.2016.01.019_bb0085) 2013; 27 Øvrevik (10.1016/j.taap.2016.01.019_bb0295) 2015; 5 Stone (10.1016/j.taap.2016.01.019_bb0365) 2009; 39 Guadagnini (10.1016/j.taap.2016.01.019_bb0140) 2015; 9 England (10.1016/j.taap.2016.01.019_bb0090) 2004; 11 Jensen (10.1016/j.taap.2016.01.019_bb0205) 2013 He (10.1016/j.taap.2016.01.019_bb0170) 2014; 22 Kroll (10.1016/j.taap.2016.01.019_bb0215) 2012; 86 Sturla (10.1016/j.taap.2016.01.019_bb0370) 2014; 27 Levine (10.1016/j.taap.2016.01.019_bb0225) 1994; 233 Dalle-Donne (10.1016/j.taap.2016.01.019_bb0045) 2003; 9 Emter (10.1016/j.taap.2016.01.019_bb0080) 2010; 245 Langmuir (10.1016/j.taap.2016.01.019_bb0220) 1996 Almroth (10.1016/j.taap.2016.01.019_bb0005) 2008; 66 Halliwell (10.1016/j.taap.2016.01.019_bb0155) 2004; 142 Papageorgiou (10.1016/j.taap.2016.01.019_bb0305) 2007; 28 Cabiscol (10.1016/j.taap.2016.01.019_bb0030) 2014; 33 Nakamura (10.1016/j.taap.2016.01.019_bb0270) 1996; 119 Monopoli (10.1016/j.taap.2016.01.019_bb0250) 2012; 7 Wardman (10.1016/j.taap.2016.01.019_bb0400) 2007; 43 Bates (10.1016/j.taap.2016.01.019_bb0015) 2015; 49 Frohnert (10.1016/j.taap.2016.01.019_bb0110) 2011; 19 Murray (10.1016/j.taap.2016.01.019_bb0260) 2013; 67 Groitl (10.1016/j.taap.2016.01.019_bb0135) 2014; 1844 Avalos (10.1016/j.taap.2016.01.019_bb0010) 2015; 25 Hayes (10.1016/j.taap.2016.01.019_bb0165) 2014; 39 Manshian (10.1016/j.taap.2016.01.019_bb0240) 2015; 9 Meng (10.1016/j.taap.2016.01.019_bb0245) 2009; 3 Verano-Braga (10.1016/j.taap.2016.01.019_bb0385) 2014; 8 Wong (10.1016/j.taap.2016.01.019_bb0405) 2010; 12 Decan (10.1016/j.taap.2016.01.019_bb0055) 2016; 796 Reczek (10.1016/j.taap.2016.01.019_bb0325) 2015; 33 Neubauer (10.1016/j.taap.2016.01.019_bb0280) 2015; 9 Zhang (10.1016/j.taap.2016.01.019_bb0410) 2015; 237 Ding (10.1016/j.taap.2016.01.019_bb0060) 2009; 241 Nel (10.1016/j.taap.2016.01.019_bb0275) 2006; 311 Pal (10.1016/j.taap.2016.01.019_bb0300) 2014; 16 Hu (10.1016/j.taap.2016.01.019_bb0190) 2014; 108 Butterfield (10.1016/j.taap.2016.01.019_bb0020) 2014; 33 Robinson (10.1016/j.taap.2016.01.019_bb0330) 1999; 266 Feeney (10.1016/j.taap.2016.01.019_bb0100) 2012; 17 Hsieh (10.1016/j.taap.2016.01.019_bb0185) 2013; 9 Huo (10.1016/j.taap.2016.01.019_bb0195) 2015; 15 Murray (10.1016/j.taap.2016.01.019_bb0265) 2009; 257 Gorlach (10.1016/j.taap.2016.01.019_bb0125) 2015; 6 Shi (10.1016/j.taap.2016.01.019_bb0340) 2003; 5 Fujita (10.1016/j.taap.2016.01.019_bb0115) 2015; 27 Butterfield (10.1016/j.taap.2016.01.019_bb0025) 2012; 17 Simmons (10.1016/j.taap.2016.01.019_bb0350) 2011; 5 Tournebize (10.1016/j.taap.2016.01.019_bb0375) 2013; 116 Madian (10.1016/j.taap.2016.01.019_bb0230) 2010; 9 Nymark (10.1016/j.taap.2016.01.019_bb0285) 2014; 11 |
References_xml | – volume: 266 start-page: 48 year: 1999 end-page: 57 ident: bb0330 article-title: Determination of protein carbonyl groups by immunoblotting publication-title: Anal. Biochem. contributor: fullname: Holmes – volume: 84 start-page: 227 year: 2015 end-page: 245 ident: bb0120 article-title: The cysteine proteome publication-title: Free Radic. Biol. Med. contributor: fullname: Jones – volume: 17 start-page: 1 year: 2015 end-page: 11 ident: bb0210 article-title: Comparison of cellular toxicity between multi-walled carbon nanotubes and onion-like shell-shaped carbon nanoparticles publication-title: J. Nanoparticle Res. contributor: fullname: Choi – volume: 11 start-page: 4 year: 2014 ident: bb0285 article-title: Free radical scavenging and formation by multi-walled carbon nanotubes in cell free conditions and in human bronchial epithelial cells publication-title: Part. Fibre Toxicol. contributor: fullname: Briede – volume: 257 start-page: 161 year: 2009 end-page: 171 ident: bb0265 article-title: Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes publication-title: Toxicol. contributor: fullname: Shvedova – start-page: 229 year: 1996 end-page: 234 ident: bb0220 article-title: New thiol active fluorophores for intracellular thiols and glutathione measurement publication-title: Fluorescence Microscopy and Fluorescent Probes contributor: fullname: Durand – volume: 114 start-page: 354 year: 2000 end-page: 364 ident: bb0345 article-title: Redox cycling of phenol induces oxidative stress in human epidermal keratinocytes publication-title: J. Invest. Dermatol. contributor: fullname: Kagan – volume: 17 start-page: 1610 year: 2012 end-page: 1655 ident: bb0025 article-title: Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications publication-title: Antioxid. Redox Signal. contributor: fullname: Sultana – volume: 77 start-page: 11 year: 2006 end-page: 18 ident: bb0070 article-title: Protein carbonylation and heat shock response in publication-title: Aquat. Toxicol. contributor: fullname: Sheehan – volume: 49 start-page: 9532 year: 2015 end-page: 9547 ident: bb0310 article-title: Adapting OECD aquatic toxicity tests for use with manufactured nanomaterials: key issues and consensus recommendations publication-title: Environ. Sci. Technol. contributor: fullname: Sayre – volume: 6 start-page: 372 year: 2015 end-page: 385 ident: bb0125 article-title: Reactive oxygen species, nutrition, hypoxia and diseases: problems solved? publication-title: Redox Biol. contributor: fullname: Kietzmann – volume: 19 start-page: 1735 year: 2011 end-page: 1741 ident: bb0110 article-title: Increased adipose protein carbonylation in human obesity publication-title: Obesity (Silver Spring) contributor: fullname: Bernlohr – volume: 27 start-page: 207 year: 2015 end-page: 223 ident: bb0115 article-title: Size effects of single-walled carbon nanotubes on in vivo and in vitro pulmonary toxicity publication-title: Inhal. Toxicol. contributor: fullname: Honda – volume: 288 start-page: 26497 year: 2013 end-page: 26504 ident: bb0130 article-title: Causes and consequences of cysteine S-glutathionylation publication-title: J. Biol. Chem. contributor: fullname: Tew – volume: 16 start-page: 1 year: 2014 end-page: 20 ident: bb0300 article-title: Screening for oxidative damage by engineered nanomaterials: a comparative evaluation of FRAS and DCFH publication-title: J. Nanoparticle Res. contributor: fullname: Bello – volume: 312 start-page: 158 year: 2013 end-page: 165 ident: bb0390 article-title: The adverse outcome pathway concept: a pragmatic tool in toxicology publication-title: Toxicology contributor: fullname: Vinken – volume: 27 start-page: 2225 year: 2013 end-page: 2232 ident: bb0085 article-title: Gene expression changes induced by skin sensitizers in the KeratinoSens cell line: discriminating Nrf2-dependent and Nrf2-independent events publication-title: Toxicol. In Vitro contributor: fullname: Natsch – volume: 25 start-page: 287 year: 2015 end-page: 295 ident: bb0010 article-title: Effects of silver and gold nanoparticles of different sizes in human pulmonary fibroblasts publication-title: Toxicol. Mech. Methods contributor: fullname: Morales – volume: 8 start-page: 223 year: 2013 end-page: 227 ident: bb0180 article-title: Intracellular oxidative stress caused by nanoparticles: what do we measure with the dichlorofluorescein assay? publication-title: Nano Today contributor: fullname: Napierska – volume: 796 start-page: 8 year: 2016 end-page: 22 ident: bb0055 article-title: Characterization of in vitro genotoxic, cytotoxic and transcriptomic responses following exposures to amorphous silica of different sizes publication-title: Mutat. Res. Genet. Toxicol. Environ. Mutagen. contributor: fullname: Halappanavar – volume: 245 start-page: 281 year: 2010 end-page: 290 ident: bb0080 article-title: Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Natsch – volume: 8 start-page: 2161 year: 2014 end-page: 2175 ident: bb0385 article-title: Insights into the cellular response triggered by silver nanoparticles using quantitative proteomics publication-title: ACS Nano contributor: fullname: Kjeldsen – volume: 9 start-page: 169 year: 2003 end-page: 176 ident: bb0045 article-title: Protein carbonylation in human diseases publication-title: Trends Mol. Med. contributor: fullname: Milzani – volume: 5 start-page: 3059 year: 2011 end-page: 3068 ident: bb0145 article-title: Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular responses publication-title: ACS Nano contributor: fullname: Luch – start-page: 1 year: 2013 end-page: 62 ident: bb0205 article-title: Deliverable 4.7: Hydrochemical Reactivity, Solubility, and Biodurability of NANOGENOTOX Nanomaterials. NANOGENOTOX contributor: fullname: Nielsen – volume: 40 start-page: 1250 year: 2006 end-page: 1258 ident: bb0355 article-title: Protein oxidation and aging publication-title: Free Radic. Res. contributor: fullname: Stadtman – volume: 233 start-page: 346 year: 1994 end-page: 357 ident: bb0225 article-title: Carbonyl assays for determination of oxidatively modified proteins publication-title: Methods Enzymol. contributor: fullname: Shacter – volume: 72 start-page: 49 year: 2015 end-page: 56 ident: bb0200 article-title: Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers publication-title: Occup. Environ. Med. contributor: fullname: Hoek – volume: 311 start-page: 622 year: 2006 end-page: 627 ident: bb0275 article-title: Toxic potential of materials at the nanolevel publication-title: Science contributor: fullname: Li – volume: 241 start-page: 260 year: 2009 end-page: 268 ident: bb0060 article-title: Size-dependent effects of tungsten carbide–cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Shvedova – volume: 126 start-page: 457 year: 2012 end-page: 468 ident: bb0150 article-title: Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses publication-title: Toxicol. Sci. contributor: fullname: Reiser – volume: 142 start-page: 231 year: 2004 end-page: 255 ident: bb0155 article-title: Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? publication-title: Br. J. Pharmacol. contributor: fullname: Whiteman – volume: 11 start-page: 252 year: 2004 end-page: 260 ident: bb0090 article-title: Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis publication-title: Cell Death Differ. contributor: fullname: Cotter – volume: 66 start-page: 271 year: 2008 end-page: 277 ident: bb0005 article-title: Protein carbonyls and antioxidant defenses in corkwing wrasse ( publication-title: Mar. Environ. Res. contributor: fullname: Forlin – volume: 5 start-page: 550 year: 2003 end-page: 556 ident: bb0340 article-title: Hydroxyl radical generation by electron paramagnetic resonance as a new method to monitor ambient particulate matter composition publication-title: J. Environ. Monit. contributor: fullname: Borm – volume: 35 start-page: 9941 year: 2014 end-page: 9950 ident: bb0235 article-title: High-content imaging and gene expression analysis to study cell–nanomaterial interactions: the effect of surface hydrophobicity publication-title: Biomaterials contributor: fullname: Soenen – volume: 5 start-page: 1 year: 2011 end-page: 12 ident: bb0350 article-title: NRF2 oxidative stress induced by heavy metals is cell type dependent publication-title: Curr. Chem. Genomics contributor: fullname: Ramabhadran – volume: 33 start-page: 8 year: 2015 end-page: 13 ident: bb0325 article-title: ROS-dependent signal transduction publication-title: Curr. Opin. Cell Biol. contributor: fullname: Chandel – volume: 220 start-page: 102 year: 2014 end-page: 115 ident: bb0360 article-title: Si/SiO publication-title: Chem. Biol. Interact. contributor: fullname: Dinischiotu – volume: 5 start-page: 1399 year: 2015 end-page: 1440 ident: bb0295 article-title: Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant- and non-oxidant-mediated triggering mechanisms publication-title: Biomolecules contributor: fullname: Schwarze – volume: 1844 start-page: 1335 year: 2014 end-page: 1343 ident: bb0135 article-title: Thiol-based redox switches publication-title: Biochim. Biophys. Acta contributor: fullname: Jakob – volume: 73 start-page: 445 year: 2010 end-page: 461 ident: bb0335 article-title: Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics publication-title: J. Toxicol. Environ. Health A contributor: fullname: Oberdorster – volume: 116 start-page: 753 year: 2013 end-page: 763 ident: bb0375 article-title: Pitfalls of assays devoted to evaluation of oxidative stress induced by inorganic nanoparticles publication-title: Talanta contributor: fullname: Boudier – volume: 1-14 year: 2015 ident: bb0320 article-title: Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro publication-title: Hum. Exp. Toxicol. contributor: fullname: Chandrasekaran – volume: 12 start-page: 1 year: 2015 end-page: 18 ident: bb0075 article-title: Proteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms publication-title: Part. Fibre Toxicol. contributor: fullname: Haase – volume: 15 start-page: 1143 year: 2015 end-page: 1149 ident: bb0195 article-title: High-content screening for assessing nanomaterial toxicity publication-title: J. Nanosci. Nanotechnol. contributor: fullname: Chen – volume: 745 start-page: 104 year: 2012 end-page: 111 ident: bb0065 article-title: In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines publication-title: Mutat. Res. contributor: fullname: Singh – volume: 43 start-page: 995 year: 2007 end-page: 1022 ident: bb0400 article-title: Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects publication-title: Free Radic. Biol. Med. contributor: fullname: Wardman – volume: 33 start-page: 21 year: 2014 end-page: 48 ident: bb0030 article-title: Protein carbonylation: proteomics, specificity and relevance to aging publication-title: Mass Spectrom. Rev. contributor: fullname: Ros – volume: 239 start-page: 205 year: 2015 end-page: 215 ident: bb0105 article-title: Comparative analysis of redox and inflammatory properties of pristine nanomaterials and commonly used semiconductor manufacturing nano-abrasives publication-title: Toxicol. Lett. contributor: fullname: Melendez – volume: 9 start-page: 13 year: 2015 end-page: 24 ident: bb0140 article-title: Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests publication-title: Nanotoxicol. contributor: fullname: Boland – volume: 9 start-page: 3766 year: 2010 end-page: 3780 ident: bb0230 article-title: Proteomic identification of carbonylated proteins and their oxidation sites publication-title: J. Proteome Res. contributor: fullname: Regnier – volume: 17 start-page: 1571 year: 2012 end-page: 1579 ident: bb0100 article-title: Tyrosine modifications in aging publication-title: Antioxid. Redox Signal. contributor: fullname: Schoneich – volume: 9 start-page: 1059 year: 2015 end-page: 1066 ident: bb0280 article-title: Size-dependent ROS production by palladium and nickel nanoparticles in cellular and acellular environments — an indication for the catalytic nature of their interactions publication-title: Nanotoxicol. contributor: fullname: Kasper – volume: 9 start-page: 1853 year: 2013 end-page: 1865 ident: bb0185 article-title: Mapping the biological oxidative damage of engineered nanomaterials publication-title: Small contributor: fullname: Rogers – volume: 49 start-page: 13605 year: 2015 end-page: 13612 ident: bb0015 article-title: Reactive oxygen species generation linked to sources of atmospheric particulate matter and cardiorespiratory effects publication-title: Environ. Sci. Technol. contributor: fullname: Russell – volume: 12 start-page: 393 year: 2010 end-page: 404 ident: bb0405 article-title: Cell signaling by protein carbonylation and decarbonylation publication-title: Antioxid. Redox Signal. contributor: fullname: Suzuki – volume: 12 start-page: 1960 year: 2013 end-page: 1967 ident: bb0315 article-title: Protein oxidation: identification and utilisation of molecular markers to differentiate singlet oxygen and hydroxyl radical-mediated oxidative pathways publication-title: Photochem. Photobiol. Sci. contributor: fullname: Dyer – volume: 33 start-page: 277 year: 2014 end-page: 301 ident: bb0020 article-title: Mass spectrometry and redox proteomics: applications in disease publication-title: Mass Spectrom. Rev. contributor: fullname: Robinson – volume: 28 start-page: 2946 year: 2007 end-page: 2958 ident: bb0305 article-title: The effect of nano- and micron-sized particles of cobalt–chromium alloy on human fibroblasts in vitro publication-title: Biomaterials contributor: fullname: Case – volume: 27 start-page: 314 year: 2014 end-page: 329 ident: bb0370 article-title: Systems toxicology: from basic research to risk assessment publication-title: Chem. Res. Toxicol. contributor: fullname: Peitsch – volume: 237 start-page: 61 year: 2015 end-page: 71 ident: bb0410 article-title: Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells publication-title: Toxicol. Lett. contributor: fullname: Nie – volume: 83 start-page: 232 year: 2015 end-page: 239 ident: bb0380 article-title: Radical scavenging reaction kinetics with multiwalled carbon nanotubes publication-title: Carbon contributor: fullname: Endo – volume: 6 start-page: 228 year: 2011 end-page: 231 ident: bb0160 article-title: Towards nanotechnology regulation — publish the unpublishable publication-title: Nano Today contributor: fullname: Lichtenbeld – volume: 9 start-page: 10431 year: 2015 end-page: 10444 ident: bb0240 article-title: High-content imaging and gene expression approaches to unravel the effect of surface functionality on cellular interactions of silver nanoparticles publication-title: ACS Nano contributor: fullname: Soenen – volume: 39 start-page: 613 year: 2009 end-page: 626 ident: bb0365 article-title: Development of in vitro systems for nanotoxicology: methodological considerations publication-title: Crit. Rev. Toxicol. contributor: fullname: Schins – volume: 10 start-page: 389 year: 2006 end-page: 406 ident: bb0040 article-title: Protein carbonylation, cellular dysfunction, and disease progression publication-title: J. Cell. Mol. Med. contributor: fullname: Milzani – volume: 86 start-page: 1123 year: 2012 end-page: 1136 ident: bb0215 article-title: Interference of engineered nanoparticles with in vitro toxicity assays publication-title: Arch. Toxicol. contributor: fullname: Schnekenburger – volume: 12 start-page: 10806 year: 2015 end-page: 10819 ident: bb0395 article-title: Effects of Nano-CeO(2) with different nanocrystal morphologies on cytotoxicity in HepG2 cells publication-title: Int. J. Environ. Res. Public Health contributor: fullname: Chen – volume: 1703 start-page: 93 year: 2005 end-page: 109 ident: bb0050 article-title: The oxidative environment and protein damage publication-title: Biochim. Biophys. Acta contributor: fullname: Davies – volume: 39 start-page: 199 year: 2014 end-page: 218 ident: bb0165 article-title: The Nrf2 regulatory network provides an interface between redox and intermediary metabolism publication-title: Trends Biochem. Sci. contributor: fullname: Dinkova-Kostova – volume: 95 start-page: 203 year: 2009 end-page: 212 ident: bb0035 article-title: Environmental ammonia exposure induces oxidative stress in gills and brain of publication-title: Aquat. Toxicol. contributor: fullname: Ip – volume: 4 start-page: 276 year: 2013 end-page: 294 ident: bb0095 article-title: Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators publication-title: Aging Dis. contributor: fullname: Karasu – volume: 7 start-page: 779 year: 2012 end-page: 786 ident: bb0250 article-title: Biomolecular coronas provide the biological identity of nanosized materials publication-title: Nat. Nanotechnol. contributor: fullname: Dawson – volume: 108 start-page: 289 year: 2014 end-page: 299 ident: bb0190 article-title: Toxicity of copper oxide nanoparticles in the blue mussel, publication-title: Chemosphere contributor: fullname: Sheehan – volume: 3 start-page: 1620 year: 2009 end-page: 1627 ident: bb0245 article-title: A predictive toxicological paradigm for the safety assessment of nanomaterials publication-title: ACS Nano contributor: fullname: Nel – volume: 234 start-page: 222 year: 2009 end-page: 235 ident: bb0255 article-title: Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Zhang – volume: 67 start-page: 461 year: 2013 end-page: 476 ident: bb0260 article-title: Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro publication-title: Cell Biochem. Biophys. contributor: fullname: Shvedova – volume: 119 start-page: 768 year: 1996 end-page: 774 ident: bb0270 article-title: Analysis of protein carbonyls with 2,4-dinitrophenyl hydrazine and its antibodies by immunoblot in two-dimensional gel electrophoresis publication-title: J. Biochem. contributor: fullname: Goto – volume: 86 start-page: 1641 year: 2012 end-page: 1646 ident: bb0175 article-title: Risk assessment of nanomaterials in cosmetics: a European union perspective publication-title: Arch. Toxicol. contributor: fullname: Gotz – volume: 22 start-page: 49 year: 2014 end-page: 63 ident: bb0170 article-title: Electron spin resonance spectroscopy for the study of nanomaterial-mediated generation of reactive oxygen species publication-title: J. Food Drug Anal. contributor: fullname: Yin – volume: 311 start-page: 622 year: 2006 ident: 10.1016/j.taap.2016.01.019_bb0275 article-title: Toxic potential of materials at the nanolevel publication-title: Science doi: 10.1126/science.1114397 contributor: fullname: Nel – volume: 245 start-page: 281 year: 2010 ident: 10.1016/j.taap.2016.01.019_bb0080 article-title: Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2010.03.009 contributor: fullname: Emter – volume: 43 start-page: 995 year: 2007 ident: 10.1016/j.taap.2016.01.019_bb0400 article-title: Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2007.06.026 contributor: fullname: Wardman – volume: 1703 start-page: 93 year: 2005 ident: 10.1016/j.taap.2016.01.019_bb0050 article-title: The oxidative environment and protein damage publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbapap.2004.08.007 contributor: fullname: Davies – volume: 8 start-page: 223 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0180 article-title: Intracellular oxidative stress caused by nanoparticles: what do we measure with the dichlorofluorescein assay? publication-title: Nano Today doi: 10.1016/j.nantod.2013.01.001 contributor: fullname: Hoet – volume: 9 start-page: 169 year: 2003 ident: 10.1016/j.taap.2016.01.019_bb0045 article-title: Protein carbonylation in human diseases publication-title: Trends Mol. Med. doi: 10.1016/S1471-4914(03)00031-5 contributor: fullname: Dalle-Donne – volume: 67 start-page: 461 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0260 article-title: Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro publication-title: Cell Biochem. Biophys. doi: 10.1007/s12013-012-9367-9 contributor: fullname: Murray – volume: 6 start-page: 372 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0125 article-title: Reactive oxygen species, nutrition, hypoxia and diseases: problems solved? publication-title: Redox Biol. doi: 10.1016/j.redox.2015.08.016 contributor: fullname: Gorlach – volume: 10 start-page: 389 year: 2006 ident: 10.1016/j.taap.2016.01.019_bb0040 article-title: Protein carbonylation, cellular dysfunction, and disease progression publication-title: J. Cell. Mol. Med. doi: 10.1111/j.1582-4934.2006.tb00407.x contributor: fullname: Dalle-Donne – volume: 126 start-page: 457 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0150 article-title: Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfs003 contributor: fullname: Haase – volume: 95 start-page: 203 year: 2009 ident: 10.1016/j.taap.2016.01.019_bb0035 article-title: Environmental ammonia exposure induces oxidative stress in gills and brain of Boleophthalmus boddarti (mudskipper) publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2009.09.004 contributor: fullname: Ching – volume: 39 start-page: 613 year: 2009 ident: 10.1016/j.taap.2016.01.019_bb0365 article-title: Development of in vitro systems for nanotoxicology: methodological considerations publication-title: Crit. Rev. Toxicol. doi: 10.1080/10408440903120975 contributor: fullname: Stone – volume: 257 start-page: 161 year: 2009 ident: 10.1016/j.taap.2016.01.019_bb0265 article-title: Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes publication-title: Toxicol. doi: 10.1016/j.tox.2008.12.023 contributor: fullname: Murray – volume: 49 start-page: 13605 issue: 22 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0015 article-title: Reactive oxygen species generation linked to sources of atmospheric particulate matter and cardiorespiratory effects publication-title: Environ. Sci. Technol. doi: 10.1021/acs.est.5b02967 contributor: fullname: Bates – volume: 33 start-page: 277 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0020 article-title: Mass spectrometry and redox proteomics: applications in disease publication-title: Mass Spectrom. Rev. doi: 10.1002/mas.21374 contributor: fullname: Butterfield – volume: 9 start-page: 1853 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0185 article-title: Mapping the biological oxidative damage of engineered nanomaterials publication-title: Small doi: 10.1002/smll.201201995 contributor: fullname: Hsieh – ident: 10.1016/j.taap.2016.01.019_bb0290 – volume: 11 start-page: 252 year: 2004 ident: 10.1016/j.taap.2016.01.019_bb0090 article-title: Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401338 contributor: fullname: England – volume: 12 start-page: 1960 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0315 article-title: Protein oxidation: identification and utilisation of molecular markers to differentiate singlet oxygen and hydroxyl radical-mediated oxidative pathways publication-title: Photochem. Photobiol. Sci. doi: 10.1039/c3pp50182e contributor: fullname: Plowman – volume: 1844 start-page: 1335 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0135 article-title: Thiol-based redox switches publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbapap.2014.03.007 contributor: fullname: Groitl – volume: 22 start-page: 49 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0170 article-title: Electron spin resonance spectroscopy for the study of nanomaterial-mediated generation of reactive oxygen species publication-title: J. Food Drug Anal. doi: 10.1016/j.jfda.2014.01.004 contributor: fullname: He – volume: 5 start-page: 550 year: 2003 ident: 10.1016/j.taap.2016.01.019_bb0340 article-title: Hydroxyl radical generation by electron paramagnetic resonance as a new method to monitor ambient particulate matter composition publication-title: J. Environ. Monit. doi: 10.1039/b303928p contributor: fullname: Shi – volume: 9 start-page: 3766 year: 2010 ident: 10.1016/j.taap.2016.01.019_bb0230 article-title: Proteomic identification of carbonylated proteins and their oxidation sites publication-title: J. Proteome Res. doi: 10.1021/pr1002609 contributor: fullname: Madian – volume: 6 start-page: 228 year: 2011 ident: 10.1016/j.taap.2016.01.019_bb0160 article-title: Towards nanotechnology regulation — publish the unpublishable publication-title: Nano Today doi: 10.1016/j.nantod.2011.03.002 contributor: fullname: Hankin – volume: 4 start-page: 276 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0095 article-title: Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators publication-title: Aging Dis. doi: 10.14336/AD.2013.0400276 contributor: fullname: Ergin – volume: 72 start-page: 49 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0200 article-title: Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers publication-title: Occup. Environ. Med. doi: 10.1136/oemed-2014-102303 contributor: fullname: Janssen – volume: 35 start-page: 9941 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0235 article-title: High-content imaging and gene expression analysis to study cell–nanomaterial interactions: the effect of surface hydrophobicity publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.08.031 contributor: fullname: Manshian – volume: 27 start-page: 207 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0115 article-title: Size effects of single-walled carbon nanotubes on in vivo and in vitro pulmonary toxicity publication-title: Inhal. Toxicol. doi: 10.3109/08958378.2015.1026620 contributor: fullname: Fujita – volume: 33 start-page: 8 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0325 article-title: ROS-dependent signal transduction publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2014.09.010 contributor: fullname: Reczek – volume: 116 start-page: 753 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0375 article-title: Pitfalls of assays devoted to evaluation of oxidative stress induced by inorganic nanoparticles publication-title: Talanta doi: 10.1016/j.talanta.2013.07.077 contributor: fullname: Tournebize – volume: 12 start-page: 1 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0075 article-title: Proteomic analysis of protein carbonylation: a useful tool to unravel nanoparticle toxicity mechanisms publication-title: Part. Fibre Toxicol. doi: 10.1186/s12989-015-0108-2 contributor: fullname: Driessen – volume: 5 start-page: 1399 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0295 article-title: Activation of proinflammatory responses in cells of the airway mucosa by particulate matter: oxidant- and non-oxidant-mediated triggering mechanisms publication-title: Biomolecules doi: 10.3390/biom5031399 contributor: fullname: Øvrevik – volume: 12 start-page: 393 year: 2010 ident: 10.1016/j.taap.2016.01.019_bb0405 article-title: Cell signaling by protein carbonylation and decarbonylation publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2009.2805 contributor: fullname: Wong – volume: 17 start-page: 1 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0210 article-title: Comparison of cellular toxicity between multi-walled carbon nanotubes and onion-like shell-shaped carbon nanoparticles publication-title: J. Nanoparticle Res. doi: 10.1007/s11051-015-3181-4 contributor: fullname: Kang – volume: 49 start-page: 9532 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0310 article-title: Adapting OECD aquatic toxicity tests for use with manufactured nanomaterials: key issues and consensus recommendations publication-title: Environ. Sci. Technol. doi: 10.1021/acs.est.5b00997 contributor: fullname: Petersen – volume: 84 start-page: 227 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0120 article-title: The cysteine proteome publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2015.03.022 contributor: fullname: Go – volume: 17 start-page: 1571 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0100 article-title: Tyrosine modifications in aging publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2012.4595 contributor: fullname: Feeney – volume: 142 start-page: 231 year: 2004 ident: 10.1016/j.taap.2016.01.019_bb0155 article-title: Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0705776 contributor: fullname: Halliwell – volume: 114 start-page: 354 year: 2000 ident: 10.1016/j.taap.2016.01.019_bb0345 article-title: Redox cycling of phenol induces oxidative stress in human epidermal keratinocytes publication-title: J. Invest. Dermatol. doi: 10.1046/j.1523-1747.2000.00865.x contributor: fullname: Shvedova – volume: 27 start-page: 2225 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0085 article-title: Gene expression changes induced by skin sensitizers in the KeratinoSens cell line: discriminating Nrf2-dependent and Nrf2-independent events publication-title: Toxicol. In Vitro doi: 10.1016/j.tiv.2013.09.009 contributor: fullname: Emter – volume: 119 start-page: 768 year: 1996 ident: 10.1016/j.taap.2016.01.019_bb0270 article-title: Analysis of protein carbonyls with 2,4-dinitrophenyl hydrazine and its antibodies by immunoblot in two-dimensional gel electrophoresis publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a021306 contributor: fullname: Nakamura – volume: 12 start-page: 10806 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0395 article-title: Effects of Nano-CeO(2) with different nanocrystal morphologies on cytotoxicity in HepG2 cells publication-title: Int. J. Environ. Res. Public Health doi: 10.3390/ijerph120910806 contributor: fullname: Wang – volume: 73 start-page: 445 year: 2010 ident: 10.1016/j.taap.2016.01.019_bb0335 article-title: Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics publication-title: J. Toxicol. Environ. Health A doi: 10.1080/15287390903489422 contributor: fullname: Rushton – volume: 312 start-page: 158 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0390 article-title: The adverse outcome pathway concept: a pragmatic tool in toxicology publication-title: Toxicology doi: 10.1016/j.tox.2013.08.011 contributor: fullname: Vinken – volume: 40 start-page: 1250 year: 2006 ident: 10.1016/j.taap.2016.01.019_bb0355 article-title: Protein oxidation and aging publication-title: Free Radic. Res. doi: 10.1080/10715760600918142 contributor: fullname: Stadtman – volume: 239 start-page: 205 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0105 article-title: Comparative analysis of redox and inflammatory properties of pristine nanomaterials and commonly used semiconductor manufacturing nano-abrasives publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2015.09.025 contributor: fullname: Flaherty – volume: 108 start-page: 289 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0190 article-title: Toxicity of copper oxide nanoparticles in the blue mussel, Mytilus edulis: a redox proteomic investigation publication-title: Chemosphere doi: 10.1016/j.chemosphere.2014.01.054 contributor: fullname: Hu – volume: 233 start-page: 346 year: 1994 ident: 10.1016/j.taap.2016.01.019_bb0225 article-title: Carbonyl assays for determination of oxidatively modified proteins publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(94)33040-9 contributor: fullname: Levine – volume: 19 start-page: 1735 year: 2011 ident: 10.1016/j.taap.2016.01.019_bb0110 article-title: Increased adipose protein carbonylation in human obesity publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2011.115 contributor: fullname: Frohnert – volume: 7 start-page: 779 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0250 article-title: Biomolecular coronas provide the biological identity of nanosized materials publication-title: Nat. Nanotechnol. doi: 10.1038/nnano.2012.207 contributor: fullname: Monopoli – volume: 5 start-page: 1 year: 2011 ident: 10.1016/j.taap.2016.01.019_bb0350 article-title: NRF2 oxidative stress induced by heavy metals is cell type dependent publication-title: Curr. Chem. Genomics doi: 10.2174/1875397301105010001 contributor: fullname: Simmons – volume: 5 start-page: 3059 year: 2011 ident: 10.1016/j.taap.2016.01.019_bb0145 article-title: Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular responses publication-title: ACS Nano doi: 10.1021/nn200163w contributor: fullname: Haase – volume: 220 start-page: 102 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0360 article-title: Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2014.06.020 contributor: fullname: Stan – volume: 237 start-page: 61 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0410 article-title: Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2015.05.021 contributor: fullname: Zhang – volume: 9 start-page: 13 issue: Suppl. 1 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0140 article-title: Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests publication-title: Nanotoxicol. doi: 10.3109/17435390.2013.829590 contributor: fullname: Guadagnini – volume: 39 start-page: 199 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0165 article-title: The Nrf2 regulatory network provides an interface between redox and intermediary metabolism publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2014.02.002 contributor: fullname: Hayes – volume: 77 start-page: 11 year: 2006 ident: 10.1016/j.taap.2016.01.019_bb0070 article-title: Protein carbonylation and heat shock response in Ruditapes decussatus following p,p′-dichlorodiphenyldichloroethylene (DDE) exposure: a proteomic approach reveals that DDE causes oxidative stress publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2005.10.011 contributor: fullname: Dowling – volume: 11 start-page: 4 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0285 article-title: Free radical scavenging and formation by multi-walled carbon nanotubes in cell free conditions and in human bronchial epithelial cells publication-title: Part. Fibre Toxicol. doi: 10.1186/1743-8977-11-4 contributor: fullname: Nymark – volume: 9 start-page: 1059 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0280 article-title: Size-dependent ROS production by palladium and nickel nanoparticles in cellular and acellular environments — an indication for the catalytic nature of their interactions publication-title: Nanotoxicol. doi: 10.3109/17435390.2015.1019585 contributor: fullname: Neubauer – volume: 796 start-page: 8 year: 2016 ident: 10.1016/j.taap.2016.01.019_bb0055 article-title: Characterization of in vitro genotoxic, cytotoxic and transcriptomic responses following exposures to amorphous silica of different sizes publication-title: Mutat. Res. Genet. Toxicol. Environ. Mutagen. doi: 10.1016/j.mrgentox.2015.11.011 contributor: fullname: Decan – volume: 8 start-page: 2161 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0385 article-title: Insights into the cellular response triggered by silver nanoparticles using quantitative proteomics publication-title: ACS Nano doi: 10.1021/nn4050744 contributor: fullname: Verano-Braga – volume: 288 start-page: 26497 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0130 article-title: Causes and consequences of cysteine S-glutathionylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.R113.461368 contributor: fullname: Grek – volume: 33 start-page: 21 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0030 article-title: Protein carbonylation: proteomics, specificity and relevance to aging publication-title: Mass Spectrom. Rev. doi: 10.1002/mas.21375 contributor: fullname: Cabiscol – volume: 27 start-page: 314 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0370 article-title: Systems toxicology: from basic research to risk assessment publication-title: Chem. Res. Toxicol. doi: 10.1021/tx400410s contributor: fullname: Sturla – volume: 3 start-page: 1620 year: 2009 ident: 10.1016/j.taap.2016.01.019_bb0245 article-title: A predictive toxicological paradigm for the safety assessment of nanomaterials publication-title: ACS Nano doi: 10.1021/nn9005973 contributor: fullname: Meng – volume: 86 start-page: 1123 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0215 article-title: Interference of engineered nanoparticles with in vitro toxicity assays publication-title: Arch. Toxicol. doi: 10.1007/s00204-012-0837-z contributor: fullname: Kroll – volume: 9 start-page: 10431 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0240 article-title: High-content imaging and gene expression approaches to unravel the effect of surface functionality on cellular interactions of silver nanoparticles publication-title: ACS Nano doi: 10.1021/acsnano.5b04661 contributor: fullname: Manshian – volume: 83 start-page: 232 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0380 article-title: Radical scavenging reaction kinetics with multiwalled carbon nanotubes publication-title: Carbon doi: 10.1016/j.carbon.2014.10.009 contributor: fullname: Tsuruoka – volume: 234 start-page: 222 year: 2009 ident: 10.1016/j.taap.2016.01.019_bb0255 article-title: Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2008.09.030 contributor: fullname: Monteiro-Riviere – volume: 1-14 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0320 article-title: Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro publication-title: Hum. Exp. Toxicol. contributor: fullname: Rajiv – volume: 66 start-page: 271 year: 2008 ident: 10.1016/j.taap.2016.01.019_bb0005 article-title: Protein carbonyls and antioxidant defenses in corkwing wrasse (Symphodus melops) from a heavy metal polluted and a PAH polluted site publication-title: Mar. Environ. Res. doi: 10.1016/j.marenvres.2008.04.002 contributor: fullname: Almroth – volume: 28 start-page: 2946 year: 2007 ident: 10.1016/j.taap.2016.01.019_bb0305 article-title: The effect of nano- and micron-sized particles of cobalt–chromium alloy on human fibroblasts in vitro publication-title: Biomaterials doi: 10.1016/j.biomaterials.2007.02.034 contributor: fullname: Papageorgiou – volume: 25 start-page: 287 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0010 article-title: Effects of silver and gold nanoparticles of different sizes in human pulmonary fibroblasts publication-title: Toxicol. Mech. Methods doi: 10.3109/15376516.2015.1025347 contributor: fullname: Avalos – volume: 15 start-page: 1143 year: 2015 ident: 10.1016/j.taap.2016.01.019_bb0195 article-title: High-content screening for assessing nanomaterial toxicity publication-title: J. Nanosci. Nanotechnol. doi: 10.1166/jnn.2015.9032 contributor: fullname: Huo – volume: 86 start-page: 1641 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0175 article-title: Risk assessment of nanomaterials in cosmetics: a European union perspective publication-title: Arch. Toxicol. doi: 10.1007/s00204-012-0944-x contributor: fullname: Henkler – volume: 17 start-page: 1610 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0025 article-title: Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2011.4109 contributor: fullname: Butterfield – start-page: 229 year: 1996 ident: 10.1016/j.taap.2016.01.019_bb0220 article-title: New thiol active fluorophores for intracellular thiols and glutathione measurement contributor: fullname: Langmuir – volume: 745 start-page: 104 year: 2012 ident: 10.1016/j.taap.2016.01.019_bb0065 article-title: In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines publication-title: Mutat. Res. doi: 10.1016/j.mrgentox.2011.09.013 contributor: fullname: Doak – volume: 266 start-page: 48 year: 1999 ident: 10.1016/j.taap.2016.01.019_bb0330 article-title: Determination of protein carbonyl groups by immunoblotting publication-title: Anal. Biochem. doi: 10.1006/abio.1998.2932 contributor: fullname: Robinson – volume: 16 start-page: 1 year: 2014 ident: 10.1016/j.taap.2016.01.019_bb0300 article-title: Screening for oxidative damage by engineered nanomaterials: a comparative evaluation of FRAS and DCFH publication-title: J. Nanoparticle Res. doi: 10.1007/s11051-013-2167-3 contributor: fullname: Pal – volume: 241 start-page: 260 year: 2009 ident: 10.1016/j.taap.2016.01.019_bb0060 article-title: Size-dependent effects of tungsten carbide–cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2009.09.004 contributor: fullname: Ding – start-page: 1 year: 2013 ident: 10.1016/j.taap.2016.01.019_bb0205 contributor: fullname: Jensen |
SSID | ssj0009441 |
Score | 2.311899 |
Snippet | Numbers of engineered nanomaterials (ENMs) are steadily increasing. Therefore, alternative testing approaches with reduced costs and high predictivity suitable... |
SourceID | osti proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 24 |
SubjectTerms | 60 APPLIED LIFE SCIENCES Acellular tests ANTIOXIDANTS BIOLOGICAL STRESS CARBONYLATION Chemical Engineering - methods ELECTRON SPIN RESONANCE FLUORESCENCE IN VITRO IN VIVO NANOMATERIALS Nanostructures - chemistry Nanostructures - toxicity OXIDATION Oxidation-Reduction Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Protein carbonylation PROTEINS Proteomics Proteomics - methods Reactive Oxygen Species - metabolism READOUT SYSTEMS SCREENING Toxicity mechanisms |
Title | A redox proteomics approach to investigate the mode of action of nanomaterials |
URI | https://dx.doi.org/10.1016/j.taap.2016.01.019 https://www.ncbi.nlm.nih.gov/pubmed/26827820 https://search.proquest.com/docview/1785241660 https://www.osti.gov/biblio/22687943 |
Volume | 299 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1Na9wwEIaHZHMplNKmX9umQYWSS-PGkiXLPi6hYdvSJYcE9iZkfcD2YIeuA82lv70zlp2l0PZQ8ME2DMgaefTamnkE8M5L24hG6kxFHjIZNMZBnAmykPsom0Z7OXALvq7K5bX8vFbrPTifamEorXKM_SmmD9F6vHM29ubZzWZDNb6SyDRrTtQoXtf7cIDTEa3VHiw-fVmuduxdKdPGeRK_nNFgrJ1JaV69tYSt5OVA7yTgzp_np1mHr9zfZegwHV08hkejjmSL1NQnsBfaQzi5TCDqu1N2taur2p6yE3a5Q1TfHcLD9LeOpSKkp7BaMAKH_mADtoEKlbdsoo2zvmObexpHYKgYGe2fw7rIUlUEnbW27VD8pvH8DK4vPl6dL7Nxp4XMSa77rCmURS0Vai-LIveCZKEqRCzKMm9q1DClEirqytXOKhGVtjYKL6rggkPFEYvnMGu7NrwElgdZ-qbwGqODtCJWQgee187nzsmytHN4P_WvuUlADTNlmn0z5A1D3jA5x6Oeg5pcYH4bFgYj_j_tjshfZEMsXEdJQ2iEWrMiIt4c3k5-NPg60RqJbUN3uzVcVwpHET73HF4kB983E40F4QVf_WejXsMDuqLcA66OYNZ_vw1vUNL0zTHsf_jJj8eB-wvbR_Ow |
link.rule.ids | 230,314,780,784,885,4502,24116,27924,27925,45585,45679 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1Na9wwEIaHdHtoIZQ0_ci2aatCyaVxY8uSZR9DaNi2yZLDBvYmZH3A9mCHrgPNpb-9M5adJdD0EPDB2B6QNfLotT3zCOCTE6bmtVCJDJlPhFcYB3EmSHzqgqhr5UTPLTifF7NL8X0pl1twMtbCUFrlEPtjTO-j9XDkaOjNo6vVimp8BZFplhlRo7KqegSPhUT1i4P6y59NnkclRFw2T-B7M14-VM7EJK_OGIJWZkXP7iTczr9np0mLD9z9IrSfjE534NmgItlxbOhz2PLNLhxcRAz1zSFbbKqq1ofsgF1sANU3u7Adv9WxWIL0AubHjLChv1kPbaAy5TUbWeOsa9nqlsXhGepFRqvnsDawWBNBe41pWpS-cTS_hMvTr4uTWTKss5BYkakuqXNpUEn5yok8Tx0nUShzHvKiSOsKFUwhuQyqtJU1kgepjAnc8dJbb1FvhPwVTJq28XvAUi8KV-dOYWwQhoeSK5-llXWptaIozBQ-j_2rryJOQ495Zj81eUOTN3Sa4VZNQY4u0HcGhcZ4_1-7ffIX2RAJ11LKEBqh0iyJhzeFj6MfNT5M9IfENL69XutMlRIlDd73FF5HB982E405wQXfPLBRH-DJbHF-ps--zX-8had0hrIQMrkPk-7XtX-H4qar3_eD9y8NqfSJ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+redox+proteomics+approach+to+investigate+the+mode+of+action+of+nanomaterials&rft.jtitle=Toxicology+and+applied+pharmacology&rft.au=Riebeling%2C+Christian&rft.au=Wiemann%2C+Martin&rft.au=Schnekenburger%2C+Juergen&rft.au=Kuhlbusch%2C+Thomas+AJ&rft.date=2016-05-15&rft.issn=0041-008X&rft.volume=299&rft.spage=24&rft.epage=29&rft_id=info:doi/10.1016%2Fj.taap.2016.01.019&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0041-008X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0041-008X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0041-008X&client=summon |