Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers
Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects. Objective: To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD. Materials and...
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| Published in | Biomarkers Vol. 15; no. 8; pp. 715 - 730 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Informa Healthcare
01.12.2010
Taylor & Francis |
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| Online Access | Get full text |
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| Abstract | Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.
Objective: To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD.
Materials and methods: Random forest modelling and a split-sample case-control approach were used to identify candidate predictors.
Results: We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14).
Conclusion: These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease. |
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| AbstractList | Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.
Objective: To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD.
Materials and methods: Random forest modelling and a split-sample case-control approach were used to identify candidate predictors.
Results: We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14).
Conclusion: These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease. Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects. To use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD. Random forest modelling and a split-sample case-control approach were used to identify candidate predictors. We identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14). These gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease. BACKGROUNDChronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.OBJECTIVETo use gene expression microarrays in peripheral blood leukocytes of current and former cigarette smokers to identify differences associated with COPD.MATERIALS AND METHODSRandom forest modelling and a split-sample case-control approach were used to identify candidate predictors.RESULTSWe identified 1013 genes and one smoking exposure variable that differentiated current and former smokers with or without COPD. This predictor set was reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE and RPL14).CONCLUSIONThese gene expression profiles represent potential biomarkers for COPD and may help increase mechanistic understanding of the disease. |
| Author | Scian, Mariano J. Joyce, Andrew R. Murrelle, E. Lenn Edmiston, Jeffery S. Zedler, Barbara K. Archer, Kellie J. |
| Author_xml | – sequence: 1 givenname: Jeffery S. surname: Edmiston fullname: Edmiston, Jeffery S. email: Jeffery.S.Edmiston@altria.com, Jeffery.S.Edmiston@altria.com organization: 1Research, Development & Engineering, Altria Client Services, Richmond, VA, USA – sequence: 2 givenname: Kellie J. surname: Archer fullname: Archer, Kellie J. email: Jeffery.S.Edmiston@altria.com, Jeffery.S.Edmiston@altria.com organization: 1Research, Development & Engineering, Altria Client Services, Richmond, VA, USA – sequence: 3 givenname: Mariano J. surname: Scian fullname: Scian, Mariano J. email: Jeffery.S.Edmiston@altria.com, Jeffery.S.Edmiston@altria.com organization: 1Research, Development & Engineering, Altria Client Services, Richmond, VA, USA – sequence: 4 givenname: Andrew R. surname: Joyce fullname: Joyce, Andrew R. email: Jeffery.S.Edmiston@altria.com, Jeffery.S.Edmiston@altria.com organization: 1Research, Development & Engineering, Altria Client Services, Richmond, VA, USA – sequence: 5 givenname: Barbara K. surname: Zedler fullname: Zedler, Barbara K. email: Jeffery.S.Edmiston@altria.com, Jeffery.S.Edmiston@altria.com organization: 1Research, Development & Engineering, Altria Client Services, Richmond, VA, USA – sequence: 6 givenname: E. Lenn surname: Murrelle fullname: Murrelle, E. Lenn email: Jeffery.S.Edmiston@altria.com, Jeffery.S.Edmiston@altria.com organization: 1Research, Development & Engineering, Altria Client Services, Richmond, VA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20887155$$D View this record in MEDLINE/PubMed |
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| Snippet | Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.
Objective: To use gene expression... Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects. To use gene expression microarrays in peripheral... BACKGROUNDChronic obstructive pulmonary disease (COPD) is an inflammatory lung disease with associated systemic effects.OBJECTIVETo use gene expression... |
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| SubjectTerms | Biomarkers - blood Case-Control Studies Cigarette smoking COPD gene expression Gene Expression Profiling Humans leukocytes Leukocytes - metabolism microarray Oligonucleotide Array Sequence Analysis Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - physiopathology random forest Respiratory Function Tests Smoking - blood |
| Title | Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers |
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