Adrenergic effect on the atrial natriuretic peptide secretion and vasoconstriction induced in the perfused rat heart by phorbol ester

• Published in: European journal of pharmacology Vol. 148; no. 3; p. 317
• Main Authors: Ruskoaho, H J, Leppäluoto, J
• Format: Journal Article
• Language: English
• Published: Netherlands 13.04.1988
• Subjects: Adrenergic alpha-Agonists - pharmacology; Adrenergic alpha-Antagonists - pharmacology; Adrenergic beta-Agonists - pharmacology; Adrenergic beta-Antagonists - pharmacology; Animals; Atrial Natriuretic Factor - metabolism; Heart - innervation; Heart - physiology; In Vitro Techniques; Male; Myocardium - metabolism; Perfusion; Phorbol Esters - pharmacology; Rats; Rats, Inbred Strains; Sympathetic Nervous System - physiology; Tetradecanoylphorbol Acetate - pharmacology; Vasoconstriction - drug effects

Infusion of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), known to stimulate protein kinase C, caused a gradual, sustained increase in perfusate immunoreactive atrial natriuretic peptide (IR-ANP) concentration and a more rapid increase in perfusion pressure in the isolated perfused ra...