Fibroblast growth factor 10 protects neuron against oxygen–glucose deprivation injury through inducing heme oxygenase-1

• Published in: Biochemical and biophysical research communications Vol. 456; no. 1; pp. 225 - 231
• Main Authors: Li, Yong-Hua, Yang, Li-Ye, Chen, Wei, Li, Ying-Ke, Yuan, Hong-Bin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.01.2015
• Subjects: 60 APPLIED LIFE SCIENCES; AMP; ANGIOGENESIS; Animals; ANOXIA; APOPTOSIS; BIOLOGICAL FUNCTIONS; Blood Glucose - metabolism; Brain Ischemia - pathology; CELL PROLIFERATION; Cell Survival; Cells, Cultured; Cerebral Cortex - metabolism; Cerebral ischemia; Extracellular Signal-Regulated MAP Kinases - metabolism; FGF10; Fibroblast Growth Factor 10 - metabolism; FIBROBLASTS; Flow Cytometry; GLUCOSE; GROWTH FACTORS; HEME; Heme Oxygenase-1 - metabolism; HEPARIN; HO-1; Humans; Immunohistochemistry; ISCHEMIA; Male; Membrane Proteins - metabolism; MICE; Mice, Inbred C57BL; NERVE CELLS; Neurons - metabolism; Neuroprotection; OXYGEN; Oxygen - metabolism; PC12 Cells; PHOSPHOTRANSFERASES; Rats; Reactive Oxygen Species - metabolism; RNA, Small Interfering - metabolism; Stroke - pathology; VIABILITY; Neuroprotection; Cerebral ischemia; HO-1; FGF10

•FGF10 attenuates OGD induced injury in cortical neuron.•FGF10 reduces OGD triggered ROS level in cortical neuron.•FGF10 induces HO-1 expression upon OGD stimuli in cortical neuron.•Knockdown of HO-1 impairs the neuroprotection of FGF10 in OGD model. Fibroblast growth factors (FGFs) are a family of...