Early Preservation of CXCR5 + PD-1 + Helper T Cells and B Cell Activation Predict the Breadth of Neutralizing Antibody Responses in Chronic HIV-1 Infection

• Published in: Journal of virology Vol. 88; no. 22; pp. 13310 - 13321
• Main Authors: Cohen, Kristen, Altfeld, Marcus, Alter, Galit, Stamatatos, Leonidas
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.11.2014
• Subjects: Antibodies, Neutralizing - blood; B-Lymphocytes - immunology; Cellular Response to Infection; Cohort Studies; HIV Antibodies - blood; HIV Infections - immunology; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; Longitudinal Studies; Programmed Cell Death 1 Receptor - analysis; Receptors, CXCR5 - analysis; T-Lymphocyte Subsets - chemistry; T-Lymphocyte Subsets - immunology; T-Lymphocytes, Helper-Inducer - chemistry; T-Lymphocytes, Helper-Inducer - immunology

Much is known about the characteristics of broadly neutralizing antibodies (bNAbs) generated during HIV-1 infection, but little is known about immunological mechanisms responsible for their development in only a minority of those infected by HIV-1. By monitoring longitudinally a cohort of HIV-1-infe...