AN ELISA FOR QUANTIFICATION OF T84.66, A MONOCLONAL ANTI-CEA ANTIBODY, IN MOUSE PLASMA

• Published in: Journal of immunoassay & immunochemistry Vol. 31; no. 1; pp. 1 - 9
• Main Authors: Urva, Shweta R., Yang, Victor C., Balthasar, Joseph P.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.01.2010
• Subjects: Animals; Antibodies, Monoclonal - blood; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacokinetics; athymic mice; Carcinoembryonic antigen; carcinoembryonic antigen (CEA); Carcinoembryonic Antigen - immunology; enzyme immunoassay; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Limit of Detection; Mice; Mice, Nude; Monoclonal antibodies; Pharmacokinetics; Reproducibility of Results; T84.66 anti-CEA antibody

T84.66 is a monoclonal antibody with high affinity and specificity for tumor-associated carcinoembryonic antigen (CEA). In this work, we have developed an enzyme linked immunosorbent assay to determine T84.66 concentrations in mouse plasma. The assay was validated with respect to precision and accur...