Multiple myeloma exacerbation following utilization of bone morphogenetic protein-2 in lateral lumbar interbody fusion: a case report and review of the literature

• Published in: The spine journal Vol. 14; no. 4; pp. e13 - e19
• Main Authors: Hughes, Alexander P., MD, Taher, Fadi, MD, Farshad, Mazda, MD, MPH, Aichmair, Alexander, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2014
• Subjects: Aged, 80 and over; Bone Morphogenetic Protein 2 - adverse effects; Bone Morphogenetic Protein 2 - therapeutic use; Bone morphogenetic protein-2; Complication; Female; Humans; Lateral lumbar interbody fusion; LLIF; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - surgery; Multiple myeloma; Multiple Myeloma - diagnosis; Multiple Myeloma - etiology; Orthopedics; Spinal Fusion - adverse effects; Spinal Fusion - methods; Tomography, X-Ray Computed; Treatment Outcome; XLIF; XLIF; Bone morphogenetic protein-2; Complication; Lateral lumbar interbody fusion; LLIF; Multiple myeloma

Abstract Background context Recent studies generated antithetic results regarding the safety of bone morphogenetic protein-2 (BMP-2) use in spine surgery, and the effect of this biologic adjunct on myeloma cells remains to be fully elucidated. Purpose The purpose of this study was to present a case...