Effects of acute ethanol intoxication during pregnancy on central dopaminergic system in male rats

• Published in: Neurotoxicology and teratology Vol. 16; no. 4; p. 385
• Main Authors: Fulginiti, S, Minetti, S A, Virgolini, M B
• Format: Journal Article
• Language: English
• Published: United States 01.07.1994
• Subjects: 3,4-Dihydroxyphenylacetic Acid - metabolism; Aging - metabolism; Alcoholic Intoxication; Amphetamine - pharmacology; Animals; Apomorphine - pharmacology; Corpus Striatum - drug effects; Corpus Striatum - growth & development; Corpus Striatum - metabolism; Dopamine - metabolism; Dose-Response Relationship, Drug; Female; Gestational Age; Male; Motor Activity - drug effects; Nucleus Accumbens - drug effects; Nucleus Accumbens - growth & development; Nucleus Accumbens - metabolism; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Stereotyped Behavior - drug effects; Synapses - drug effects; Synapses - metabolism

Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMP...