Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons

• Published in: Hearing research Vol. 346; pp. 14 - 24
• Main Authors: Shi, Wei, Lu, Yong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017
• Subjects: Action Potentials - drug effects; Animals; Cellular excitability; Chick Embryo; Cochlear Nucleus - cytology; Cochlear Nucleus - physiology; Excitatory Postsynaptic Potentials - drug effects; GABA-B Receptor Agonists - pharmacology; GABABR; Glutamic Acid - physiology; mGluR; Neuromodulation; Neurons - drug effects; Neurons - physiology; Nucleus angularis; Patch-Clamp Techniques; Receptors, GABA-B - physiology; Receptors, Metabotropic Glutamate - agonists; Receptors, Metabotropic Glutamate - classification; Receptors, Metabotropic Glutamate - physiology; Synaptic transmission; Synaptic Transmission - drug effects; ILD; Nucleus angularis; EPSCs; ACSF; Neuromodulation; mGluR; AP; LLDp; GABABR; NA; PPR; SON; RMP; Synaptic transmission; ITD; GPCR; VGCC; Cellular excitability; NL; NM; GABA(B)R

Neurons in the avian cochlear nucleus angularis (NA) receive glutamatergic input from the auditory nerve, and GABAergic input from the superior olivary nucleus. Physiologically heterogeneous, NA neurons perform multiple functions including encoding sound intensity information. Using in vitro whole-c...