Serum long non coding RNA MALAT-1 protected by exosomes is up-regulated and promotes cell proliferation and migration in non-small cell lung cancer

• Published in: Biochemical and biophysical research communications Vol. 490; no. 2; pp. 406 - 414
• Main Authors: Zhang, Rui, Xia, Yuhong, Wang, Zhixin, Zheng, Jie, Chen, Yafei, Li, Xiaoli, Wang, Yu, Ming, Huaikun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.08.2017
• Subjects: 60 APPLIED LIFE SCIENCES; APOPTOSIS; BIOLOGICAL MARKERS; biomarkers; blood serum; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; CELL CYCLE; Cell Line, Tumor; Cell Movement; CELL PROLIFERATION; COLONY FORMATION; DIAGNOSIS; Diagnostic marker; Exosomes; Exosomes - genetics; Exosomes - pathology; flow cytometry; Gene Expression Regulation, Neoplastic; HEALING; Humans; IN VITRO; in vitro studies; Lung - pathology; lung neoplasms; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - pathology; LUNGS; Lymphatic Metastasis - diagnosis; Lymphatic Metastasis - genetics; Lymphatic Metastasis - pathology; MALAT-1; METASTASES; metastasis; Migration; neoplasm cells; NEOPLASMS; non-coding RNA; Non-small cell lung cancer; PATIENTS; Prognosis; Proliferation; RNA; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; small interfering RNA; TUMOR CELLS; Up-Regulation; WOUNDS; Diagnostic marker; Proliferation; Exosomes; Migration; Non-small cell lung cancer; MALAT-1

Circulating lncRNAs have been defined as a novel biomarker for non-small cell lung cancer (NSCLC), MALAT-1 was first identified lncRNA that was related to lung cancer metastasis. However, the relationship between exosomal lncRNAs and the diagnosis and prognosis of NSCLC was poorly understood. The ai...