Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

• Published in: Molecular cancer Vol. 24; no. 1; pp. 71 - 24
• Main Authors: Xie, Xiaowen, Liu, Weici, Yuan, Zhiyuan, Chen, Hanqing, Mao, Wenjun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.03.2025; BioMed Central; BMC
• Subjects: Amino acids; Animals; B cells; Cancer; Development and progression; DNA Methylation; Epigenesis, Genetic; Epigenomics; Epigenomics - methods; Gene Expression Regulation, Neoplastic; Health aspects; Humans; Immunometabolism; Immunotherapy; Immunotherapy - methods; Metabolic reprogramming; Metabolites; Metastasis; Methylation; Neoplasms - etiology; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Oncology, Experimental; Review; ScATAC-seq; Spatial metabolomics; Tumor; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Immunometabolism; Epigenomics; Cancer treatment; ScATAC-seq; Tumor; Metabolic reprogramming; Spatial metabolomics

Epigenomic modifications-such as DNA methylation, histone acetylation, and histone methylation-and their implications in tumorigenesis, progression, and treatment have emerged as a pivotal field in cancer research. Tumors undergo metabolic reprogramming to sustain proliferation and metastasis in nut...