Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis
T-cell lines have been derived from aeroallergen-induced eczematous patch test sites of patients with atopic dermatitis (AD). Biopsy specimens were obtained 24 hours after allergen application to the skin, and only in vivo-activated T cells were propagated. From one patient, the T-cell lines were su...
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Published in | Journal of allergy and clinical immunology Vol. 90; no. 2; pp. 184 - 193 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Mosby, Inc
01.08.1992
Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | T-cell lines have been derived from aeroallergen-induced eczematous patch test sites of patients with atopic dermatitis (AD). Biopsy specimens were obtained 24 hours after allergen application to the skin, and only in vivo-activated T cells were propagated. From one patient, the T-cell lines were subcloned at 0.3 cells per well. With allergen-induced interleukin (IL) production, all clones tested (n = 13) were found to be specific for the allergen, producing IL-4 and granulocyte-macrophage-colony-stimulating factor. No IL-2 or interferon-γ was found. The allergen-specific proliferative response of these clones, although the response was dependent on exogenous IL-2 or IL-4, also proved that all clones were allergen specific. Under optimal stimulation (aCD3 plus phorbol myristate acetate), 15% of the clones appeared to be of Th0 phenotype and 70% of Th2 phenotype. In 15% of the clones, IL-4 was produced in the absence of IL-2, IL-5, or interferon-γ. Supernatants of all clones tested induced IgE production by B cells from normal non-atopic donors. The T-cell lines of the other patient demonstrated similar results; allergen-specific proliferation was dependent on exogenous IL-2 or IL-4 and stimulation with aCD3 plus phorbol myristate acetate demonstrated that the T cells in these lines were of the Th2 phenotype. In conclusion, our data reveal that, in AD, percutaneous sensitization to aeroallergens may occur and indicate that allergen-specific Th2 type T cells may be responsible for the high levels of (specific) IgE found in 80% of patients with AD. |
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AbstractList | T-cell lines have been derived from aeroallergen-induced eczematous patch test sites of patients with atopic dermatitis (AD). Biopsy specimens were obtained 24 hours after allergen application to the skin, and only in vivo-activated T cells were propagated. From one patient, the T-cell lines were subcloned at 0.3 cells per well. With allergen-induced interleukin (IL) production, all clones tested (n = 13) were found to be specific for the allergen, producing IL-4 and granulocyte-macrophage - colony-stimulating factor. No IL-2 or interferon- gamma was found. The allergen-specific proliferative response of these clones, although the response was dependent on exogenous IL-2 or IL-4, also proved that all clones were allergen specific. Our data reveal that, in AD, percutaneous sensitization to aeroallergens may occur and indicate that allergen-specific Th2 type T cells may be responsible for the high levels of (specific) IgE found in 80% of patients with AD. T-cell lines have been derived from aeroallergen-induced eczematous patch test sites of patients with atopic dermatitis (AD). Biopsy specimens were obtained 24 hours after allergen application to the skin, and only in vivo-activated T cells were propagated. From one patient, the T-cell lines were subcloned at 0.3 cells per well. With allergen-induced interleukin (IL) production, all clones tested (n = 13) were found to be specific for the allergen, producing IL-4 and granulocyte-macrophage-colony-stimulating factor. No IL-2 or interferon-γ was found. The allergen-specific proliferative response of these clones, although the response was dependent on exogenous IL-2 or IL-4, also proved that all clones were allergen specific. Under optimal stimulation (aCD3 plus phorbol myristate acetate), 15% of the clones appeared to be of Th0 phenotype and 70% of Th2 phenotype. In 15% of the clones, IL-4 was produced in the absence of IL-2, IL-5, or interferon-γ. Supernatants of all clones tested induced IgE production by B cells from normal non-atopic donors. The T-cell lines of the other patient demonstrated similar results; allergen-specific proliferation was dependent on exogenous IL-2 or IL-4 and stimulation with aCD3 plus phorbol myristate acetate demonstrated that the T cells in these lines were of the Th2 phenotype. In conclusion, our data reveal that, in AD, percutaneous sensitization to aeroallergens may occur and indicate that allergen-specific Th2 type T cells may be responsible for the high levels of (specific) IgE found in 80% of patients with AD. T-cell lines have been derived from aeroallergen-induced eczematous patch test sites of patients with atopic dermatitis (AD). Biopsy specimens were obtained 24 hours after allergen application to the skin, and only in vivo-activated T cells were propagated. From one patient, the T-cell lines were subcloned at 0.3 cells per well. With allergen-induced interleukin (IL) production, all clones tested (n = 13) were found to be specific for the allergen, producing IL-4 and granulocyte-macrophage-colony-stimulating factor. No IL-2 or interferon-gamma was found. The allergen-specific proliferative response of these clones, although the response was dependent on exogenous IL-2 or IL-4, also proved that all clones were allergen specific. Under optimal stimulation (aCD3 plus phorbol myristate acetate), 15% of the clones appeared to be of Th0 phenotype and 70% of Th2 phenotype. In 15% of the clones, IL-4 was produced in the absence of IL-2, IL-5, or interferon-gamma. Supernatants of all clones tested induced IgE production by B cells from normal non-atopic donors. The T-cell lines of the other patient demonstrated similar results; allergen-specific proliferation was dependent on exogenous IL-2 or IL-4 and stimulation with aCD3 plus phorbol myristate acetate demonstrated that the T cells in these lines were of the Th2 phenotype. In conclusion, our data reveal that, in AD, percutaneous sensitization to aeroallergens may occur and indicate that allergen-specific Th2 type T cells may be responsible for the high levels of (specific) IgE found in 80% of patients with AD. |
Author | van Reijsen, F.C. Romagnani, S. Maggi, E. Mudde, G.C. Westland, J.K.T. Bruijnzeel-Koomen, C.A.F.M. Kalthoff, F.S. |
Author_xml | – sequence: 1 givenname: F.C. surname: van Reijsen fullname: van Reijsen, F.C. organization: Davos, Switzerland – sequence: 2 givenname: C.A.F.M. surname: Bruijnzeel-Koomen fullname: Bruijnzeel-Koomen, C.A.F.M. organization: Davos, Switzerland – sequence: 3 givenname: F.S. surname: Kalthoff fullname: Kalthoff, F.S. organization: Davos, Switzerland – sequence: 4 givenname: E. surname: Maggi fullname: Maggi, E. organization: Davos, Switzerland – sequence: 5 givenname: S. surname: Romagnani fullname: Romagnani, S. organization: Davos, Switzerland – sequence: 6 givenname: J.K.T. surname: Westland fullname: Westland, J.K.T. organization: Davos, Switzerland – sequence: 7 givenname: G.C. surname: Mudde fullname: Mudde, G.C. organization: Davos, Switzerland |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5546107$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/1380019$$D View this record in MEDLINE/PubMed |
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Keywords | TCR RT Dpr epicutaneous patch tests GaH-IgE-biot INF-γ EFT GaM ABS FITC FcR rIL Atopic dermatitis GM-CSF a-alpha/beta TCR PBS AD a-IL EBV-B PMA allergen-specific Th2 cells GP CM LST Dermatophagoides pteronyssinus APC LC FCS a-IgE AP-strept Human Immunopathology Allergy Skin disease Pathogenesis Helper cell Phenotype Specificity T-Lymphocyte Aerosols Skin Allergen Clone |
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PublicationTitle | Journal of allergy and clinical immunology |
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PublicationYear | 1992 |
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References | Le Gros, Ben-Sasson, Seder, Finkelman, Paul (BIB25) 1990; 172 Mudde, Van Reijsen, Boland, De Gast, Bruijnzeel, Bruijnzeel-Koomen (BIB10) 1990; 69 Paliard, De Vries, Spits (BIB26) 1991; 135 Langhoff, Steinman (BIB13) 1989; 169 Reinhold, Kukel, Goeden, Neumann, Wehrmann, Kreysel (BIB24) 1991; 96 Norris, Schofield, Camp (BIB4) 1988; 118 Bruijnzeel-Koomen, Van der Donk, Bruijnzeel, Capron, De Gast, Mudde (BIB8) 1988; 74 Swain, Weinberg, English, Huston (BIB22) 1990; 145 Juhlin, Johansson, Bennich, Hogman, Thyresson (BIB1) 1969; 100 Mudde, Van Dam, De Gast (BIB20) 1986; 64 Mitchell, Chapman, Pope, Crow, Jouhal, Platts-Mills (BIB5) 1982; 1 Firestein, Roeder, Laxer (BIB21) 1989; 143 Adinoff, Tellez, Clark (BIB7) 1988; 81 Wierenga, Snoek, Bos, Jansen, Kapsenberg (BIB32) 1990; 20 Wierenga, Snoek, De Groot (BIB31) 1990; 144 Kalthoff, Rossiter, Liehl (BIB23) 1991; 27 Del Prete, De Carli, Mastromauro (BIB15) 1991; 88 Reitamo, Visa, Kahonen, Kyhk, Stubb, Salo (BIB6) 1986; 114 Hanifin, Rajka (BIB12) 1980; 92 Ramb-Lindhauer, Feldmann, Rotte, Neumann (BIB28) 1991; 283 MacKie, Cobb, Cochrane, Thompson (BIB2) 1979; 4 Bruijnzeel-Koomen, Boland, Mudde (BIB9) 1988 Rolink, Melchers, Palacios (BIB17) 1989; 169 Bruijnzeel-Koomen, Wichen v, Spry, Venge, Bruijnzeel (BIB3) 1988; 118 Parronchi, Macchia, Piccinni (BIB16) 1991; 88 Chrétien, Helm, Marsh, Padlan, Wijdenes, Banchereau (BIB11) 1988; 141 Mudde, Van Reijsen, Bruijnzeel-Koomen (BIB27) 1992 Van der Heijden, Wierenga, Bos, Kapsenberg (BIB29) 1991; 97 Chang, Shea, Urioste, Thompson, Boom, Abbas (BIB30) 1990; 145 Maggi, Del Prete, Macchia (BIB18) 1988; 18 Vercelli, Jabara, Arai, Geha (BIB19) 1989; 169 Walker, Pichler, Koponen, Domzig, De Weck (BIB14) 1986; 101 |
References_xml | – volume: 81 start-page: 736 year: 1988 end-page: 742 ident: BIB7 article-title: Atopic dermatitis and aeroallergen contact sensitivity publication-title: J Allergy Clin Immunol contributor: fullname: Clark – start-page: 335 year: 1988 end-page: 341 ident: BIB9 article-title: IgE-mediated antigen presentation by epidermal Langerhans cells from patients with atopic dermatitis publication-title: The Langerhans cell contributor: fullname: Mudde – volume: 20 start-page: 1519 year: 1990 end-page: 1526 ident: BIB32 article-title: Comparison of diversity and function of house dust mite-specific T lymphocyte clones from atopic and non-atopic donors publication-title: Eur J Immunol contributor: fullname: Kapsenberg – volume: 18 start-page: 1045 year: 1988 end-page: 1050 ident: BIB18 article-title: Profiles of lymphokine activities and helper function for IgE in human T cell clones publication-title: Eur J Immunol contributor: fullname: Macchia – volume: 88 start-page: 4538 year: 1991 end-page: 4592 ident: BIB16 article-title: Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production publication-title: Proc Natl Acad Sci USA contributor: fullname: Piccinni – volume: 74 start-page: 137 year: 1988 end-page: 142 ident: BIB8 article-title: Associated expression of CD1 antigen and the Fc receptor for IgE on epidermal Langerhans cells from patients with atopic dermatitis publication-title: Clin Exp Immunol contributor: fullname: Mudde – volume: 143 start-page: 518 year: 1989 end-page: 525 ident: BIB21 article-title: A new murine CD4 publication-title: J Immunol contributor: fullname: Laxer – volume: 92 start-page: 44 year: 1980 end-page: 47 ident: BIB12 article-title: Diagnostic features of atopic dermatitis publication-title: Acta Derm Venereol (Stockh) contributor: fullname: Rajka – volume: 169 start-page: 1693 year: 1989 end-page: 1701 ident: BIB17 article-title: Monoclonal antibodies reactive with the mouse interleukin-5 receptor publication-title: J Exp Med contributor: fullname: Palacios – volume: 135 start-page: 383 year: 1991 end-page: 393 ident: BIB26 article-title: Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2 publication-title: Cell Immunol contributor: fullname: Spits – volume: 96 start-page: 370 year: 1991 end-page: 375 ident: BIB24 article-title: Interleukin-4 promotes the expansion of skin-infiltrating lymphocytes from atopic dermatitis in vitro publication-title: J Invest Dermatol contributor: fullname: Kreysel – volume: 169 start-page: 315 year: 1989 end-page: 320 ident: BIB13 article-title: Clonal expansion of human T lymphocytes initiated by dendritic cells publication-title: J Exp Med contributor: fullname: Steinman – volume: 88 start-page: 346 year: 1991 end-page: 350 ident: BIB15 article-title: Purified protein derivative of publication-title: J Clin Invest contributor: fullname: Mastromauro – volume: 1 start-page: 127 year: 1982 end-page: 130 ident: BIB5 article-title: Basophils in allergen-induced patch test sites in atopic dermatitis publication-title: Lancet contributor: fullname: Platts-Mills – volume: 101 start-page: 195 year: 1986 end-page: 203 ident: BIB14 article-title: Different effects of IL-2 addition or antibody cross-linking on T-cell subset stimulation by CD3 antibodies publication-title: Cell Immunol contributor: fullname: De Weck – volume: 4 start-page: 187 year: 1979 end-page: 195 ident: BIB2 article-title: Total and specific IgE levels in patients with atopic dermatitis publication-title: Clin Exp Dermatol contributor: fullname: Thompson – volume: 145 start-page: 3796 year: 1990 end-page: 3806 ident: BIB22 article-title: IL-4 directs the development of Th2-like helper effectors publication-title: J Immunol contributor: fullname: Huston – volume: 144 start-page: 4651 year: 1990 end-page: 4656 ident: BIB31 article-title: Evidence for compartmentalization of functional subsets of CD4 publication-title: J Immunol contributor: fullname: De Groot – volume: 27 start-page: 141 year: 1991 end-page: 150 ident: BIB23 article-title: Differential induction of cytokine-specific mRNA in human PBL after in vitro culture with either IL-2 or IL-4 publication-title: Immunol Lett contributor: fullname: Liehl – start-page: 247 year: 1992 end-page: 252 ident: BIB27 article-title: Percutaneous sensitization to aeroallergens in atopic dermatitis publication-title: Highlights in allergology and clinical immunology contributor: fullname: Bruijnzeel-Koomen – volume: 283 start-page: 71 year: 1991 end-page: 76 ident: BIB28 article-title: Characterization of grass pollen reactive T-cell lines derived from lesional atopic skin publication-title: Arch Dermatol Res contributor: fullname: Neumann – volume: 118 start-page: 229 year: 1988 end-page: 238 ident: BIB3 article-title: Active participation of eosinophils in patch test reactions to inhalent allergens in patients with atopic dermatitis publication-title: Br J Dermatol contributor: fullname: Bruijnzeel – volume: 169 start-page: 1295 year: 1989 end-page: 1307 ident: BIB19 article-title: Induction of human IgE synthesis requires interleukin-4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens publication-title: J Exp Med contributor: fullname: Geha – volume: 69 start-page: 335 year: 1990 end-page: 341 ident: BIB10 article-title: Allergen presentation by epidermal Langerhans' cells from patients with atopic dermatitis is mediated by IgE publication-title: Immunology contributor: fullname: Bruijnzeel-Koomen – volume: 64 start-page: 150 year: 1986 end-page: 157 ident: BIB20 article-title: Human peripheral blood B cell subpopulations: surface IgD positive cells respond to pokeweed mitogen with plasma cell differentiation publication-title: Clin Exp Immunol contributor: fullname: De Gast – volume: 100 start-page: 12 year: 1969 end-page: 16 ident: BIB1 article-title: Immunoglobulin E in dermatoses publication-title: Arch Dermatol contributor: fullname: Thyresson – volume: 118 start-page: 435 year: 1988 end-page: 440 ident: BIB4 article-title: A study of the role of house dust mite in atopic dermatitis publication-title: Br J Dermatol contributor: fullname: Camp – volume: 114 start-page: 303 year: 1986 end-page: 309 ident: BIB6 article-title: Eczematous reactions in atopic dermatitis patients caused by epicutaneous testing with inhalant allergens publication-title: Br J Dermatol contributor: fullname: Salo – volume: 172 start-page: 921 year: 1990 end-page: 929 ident: BIB25 article-title: Generation of interleukin-4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells publication-title: J Exp Med contributor: fullname: Paul – volume: 97 start-page: 389 year: 1991 end-page: 394 ident: BIB29 article-title: High frequency of IL-4-producing CD4 publication-title: J Invest Dermatol contributor: fullname: Kapsenberg – volume: 145 start-page: 2803 year: 1990 end-page: 2808 ident: BIB30 article-title: Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells publication-title: J Immunol contributor: fullname: Abbas – volume: 141 start-page: 3128 year: 1988 end-page: 3134 ident: BIB11 article-title: A monoclonal anti-IgE antibody against an epitope (aminoacids 367–376) in the C3 domain inhibits IgE binding to the low affinity IgE receptor (CD23) publication-title: J Immunol contributor: fullname: Banchereau |
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Snippet | T-cell lines have been derived from aeroallergen-induced eczematous patch test sites of patients with atopic dermatitis (AD). Biopsy specimens were obtained 24... |
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SubjectTerms | allergen-specific Th2 cells Allergens - immunology Allergic diseases Antigens - immunology Atopic dermatitis B-Lymphocytes - immunology Biological and medical sciences Cell Division - drug effects Clone Cells Cytokines - metabolism Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Dermatophagoides pteronyssinus epicutaneous patch tests Epitopes Humans Immunoglobulin E - biosynthesis Immunopathology Interleukin-2 - pharmacology Medical sciences Phenotype Reference Values Skin - immunology Skin - pathology Skin allergic diseases. Stinging insect allergies T-Lymphocytes - immunology T-Lymphocytes - metabolism |
Title | Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis |
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