Comparison of Various Injectable Protein-Loaded Biodegradable Poly(Lactide-co-glycolide) (PLGA) Devices: In-Situ-Formed Implant Versus In-Situ-Formed Microspheres Versus Isolated Microspheres

The purpose of this research was to prepare various injectable, protein (cytochrome c) -loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices by a novel microencapsulation method and to compare their characteristics. Syringeable mixtures of polymer and protein solidified upon injection when...

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Bibliographic Details
Published inPharmaceutical development and technology Vol. 5; no. 2; pp. 201 - 207
Main Authors Jain, Rajeev A., Rhodes, Christopher T., Railkar, Aruna M., Malick, A. Waseem, Shah, Navnit H.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.2000
Taylor & Francis
Subjects
Controlled release
cytochrome c
Cytochrome c Group - administration & dosage
Cytochrome c Group - chemistry
Delayed-Action Preparations
Drug Carriers
Drug Compounding
Drug Implants
Implant
In situ
Isolated
Lactic Acid
Microspheres
Particle Size
PLGA
poly(lactide-co-glycolide)
Polyglycolic Acid
Polymers
Protein
Proteins - administration & dosage
Proteins - chemistry
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Summary:The purpose of this research was to prepare various injectable, protein (cytochrome c) -loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices by a novel microencapsulation method and to compare their characteristics. Syringeable mixtures of polymer and protein solidified upon injection when coming in contact with water, and formed a solid matrix-type implant or microspheres (in-situ-formed implant or in-situ-formed microspheres, respectively) with cytochrome c entrapped. These devices exhibited different characteristics in terms of in vitro cytochrome c release profile, percentage cytochrome c encapsulation efficiency, and particle size. The burst effect from these devices exhibited the following trend: in-situ-formed implant > in-situ-formed microspheres > isolated microspheres. The in-situ-formed microspheres were larger in size than the isolated microspheres. Also, the isolated microspheres exhibited the slowest release of cytochrome c, whereas the in-situ-formed implant exhibited the fastest release. The microencapsulation process can produce various drug-loaded injectable biodegradable PLGA devices having different characteristics.
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ISSN:1083-7450
1097-9867
DOI:10.1081/PDT-100100535