Antitumor Activity of Enterococcus faecalis FK-23 Preparation against Murine Syngeneic Tumors
The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administratio...
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| Published in | YAKUGAKU ZASSHI Vol. 113; no. 5; pp. 396 - 399 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese English |
| Published |
Japan
The Pharmaceutical Society of Japan
01.05.1993
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice. |
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| AbstractList | The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice. |
| Author | KIMURA, Sadao YAMAZAKI, Masatoshi OHASI, Kazutomo ABE, Shigeru SATONAKA, Katsuhito YAMAGUCHI, Hideyo YAMAMOTO, Tetsuro |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8336282$$D View this record in MEDLINE/PubMed |
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| References | 5) H. Nakajima, S. Abe, Y. Masuko, J. Tsubouchi, M. Yamazaki, D. Mizuno, Gann, 72, 723(1981). 2) S. Abe, J. Tsubouchi, K. Takahashi, M. Yamazaki, D. Mizuno, Gann, 73, 961(1982). 3) M. Yamazaki, H. Shinoda, D. Mizuno, Gann, 67, 651(1976). 1) 大橋一智, 上田浩史, 山崎正利, 木村貞夫, 安部茂, 山口英世, 薬誌, 112, 919(1992). 4) M. J. Berendt, R. J. North, J. Exp. Med. , 151, 69(1980). |
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| SubjectTerms | Animals antitumor activity Biological Products - therapeutic use Combined Modality Therapy Cyclophosphamide - therapeutic use Enterococcus faecalis FK-23 Male Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - therapy Mice Mice, Inbred C3H Mitomycin - therapeutic use MM46 tumor Neoplasm Transplantation Sarcoma, Experimental - metabolism Sarcoma, Experimental - therapy TNF Tumor Necrosis Factor-alpha - metabolism |
| Title | Antitumor Activity of Enterococcus faecalis FK-23 Preparation against Murine Syngeneic Tumors |
| URI | https://www.jstage.jst.go.jp/article/yakushi1947/113/5/113_5_396/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/8336282 |
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