Antitumor Activity of Enterococcus faecalis FK-23 Preparation against Murine Syngeneic Tumors

• Published in: YAKUGAKU ZASSHI Vol. 113; no. 5; pp. 396 - 399
• Main Authors: OHASI, Kazutomo, SATONAKA, Katsuhito, YAMAMOTO, Tetsuro, YAMAZAKI, Masatoshi, KIMURA, Sadao, ABE, Shigeru, YAMAGUCHI, Hideyo
• Format: Journal Article
• Language: Japanese; English
• Published: Japan The Pharmaceutical Society of Japan 01.05.1993
• Subjects: Animals; antitumor activity; Biological Products - therapeutic use; Combined Modality Therapy; Cyclophosphamide - therapeutic use; Enterococcus faecalis; FK-23; Male; Mammary Neoplasms, Experimental - metabolism; Mammary Neoplasms, Experimental - therapy; Mice; Mice, Inbred C3H; Mitomycin - therapeutic use; MM46 tumor; Neoplasm Transplantation; Sarcoma, Experimental - metabolism; Sarcoma, Experimental - therapy; TNF; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0031-6903; 1347-5231
• DOI: 10.1248/yakushi1947.113.5_396

The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice.