Effects of organophosphates on rabbit pyramidal cells firing pattern and hippocampal theta rhythm
The effects of the irreversible acetylcholinesterase (AChE) antagonist paraoxon (Px) on hippocampal neurophysiology were investigated and compared to those of physostigmine in urethane-anaesthetized rabbits. Hippocampal CA1 EEG signals were analyzed by power spectra. Following intracarotid administr...
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| Published in | Brain research bulletin Vol. 33; no. 3; pp. 241 - 248 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
1994
Elsevier Science |
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| Abstract | The effects of the irreversible acetylcholinesterase (AChE) antagonist paraoxon (Px) on hippocampal neurophysiology were investigated and compared to those of physostigmine in urethane-anaesthetized rabbits. Hippocampal CA1 EEG signals were analyzed by power spectra. Following intracarotid administration, the two drugs induced a similar fundamental low-frequency theta power peak while the appearance of a second theta harmonic was commonly found under Px. Again, inhibition of CA1 pyramidal cells firing was significantly more pronounced after Px injection than after physostigmine. A potent inhibitory action was also described following local Px iontophoretic application. However, a discrepancy appeared between the effects of Px and the classical cholinergic drugs (acetylcholine, physostigmine). The results indicate that Px and physostigmine have a rather similar influence on the septo-hippocampal pathway and support suggestions that Px could act within local hippocampal circuitry through other systems than the cholinergic system exclusively. |
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| AbstractList | The effects of the irreversible acetylcholinesterase (AChE) antagonist paraoxon (Px) on hippocampal neurophysiology were investigated and compared to those of physostigmine in urethane-anaesthetized rabbits. Hippocampal CA1 EEG signals were analyzed by power spectra. Following intracarotid administration, the two drugs induced a similar fundamental low-frequency theta power peak while the appearance of a second theta harmonic was commonly found under Px. Again, inhibition of CA1 pyramidal cells firing was significantly more pronounced after Px injection than after physostigmine. A potent inhibitory action was also described following local Px iontophoretic application. However, a discrepancy appeared between the effects of Px and the classical cholinergic drugs (acetylcholine, physostigmine). The results indicate that Px and physostigmine have a rather similar influence on the septo-hippocampal pathway and support suggestions that Px could act within local hippocampal circuitry through other systems than the cholinergic system exclusively. |
| Author | Breton, Patrick Nio, Jacques |
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| Cites_doi | 10.1016/0048-3575(83)90125-6 10.1016/S0003-2670(01)83670-9 10.1016/0304-3940(89)90506-5 10.1007/BF03159904 10.1016/0013-4694(85)90952-6 10.1007/BF00697391 10.1016/S0304-3940(85)80116-6 10.1111/j.1471-4159.1979.tb04581.x 10.1113/jphysiol.1971.sp009467 10.1016/0013-4694(69)90092-3 10.1037/h0076211 10.1016/0304-3940(87)90566-0 10.1016/0006-8993(77)90004-X 10.1016/0304-3940(90)90653-Q 10.1016/0014-4886(75)90195-8 10.1016/0165-0173(83)90037-1 10.1007/BF00584692 10.1038/301710a0 10.1016/0006-8993(88)90746-9 10.1016/0304-3940(85)90400-8 10.1111/j.1471-4159.1976.tb02618.x 10.1093/brain/90.3.521 10.1136/jnnp.37.7.841 10.1021/ac60041a027 10.1016/0006-8993(85)91042-X 10.1016/0014-4886(83)90409-0 10.1016/0304-3940(83)90126-X |
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| Keywords | Physostigmine Extracellular recording Pyramidal cells Hippocampus Organophosphates Toxicity Central nervous system Discharge pattern Rabbit Lagomorpha Cholinergic pathway Vertebrata Mammalia Animal Acetylcholine Organophosphorus compounds Anticholinesterase agent Pyramidal neuron θ-Rhythm Brain (vertebrata) |
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| SubjectTerms | Animals Biological and medical sciences Carotid Arteries Chemical and industrial products toxicology. Toxic occupational diseases Electroencephalography Extracellular recording Female Hippocampus Hippocampus - drug effects Hippocampus - physiology Injections, Intra-Arterial Iontophoresis Male Medical sciences Organophosphates Organophosphorus Compounds - pharmacology Paraoxon - pharmacology Physostigmine Physostigmine - pharmacology Pyramidal cells Pyramidal Cells - drug effects Pyramidal Cells - physiology Rabbits Theta Rhythm - drug effects Toxicology Various organic compounds |
| Title | Effects of organophosphates on rabbit pyramidal cells firing pattern and hippocampal theta rhythm |
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