Gum mastic increases maspin expression in prostate cancer cells

• Published in: Acta pharmacologica Sinica Vol. 28; no. 4; pp. 567 - 572
• Main Authors: HE, Mei-lan, CHEN, Wei-wen, ZHANG, Peng-ju, JIANG, An-li, FAN, Wei, YUAN, Hui-qing, LIU, Wen-wen, ZHANG, Jian-ye
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.04.2007
• Subjects: Cell Line, Tumor; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Humans; Male; maspin; Mastic Resin; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Receptors, Androgen - drug effects; Receptors, Androgen - metabolism; Resins, Plant - pharmacology; Serpins - biosynthesis; Serpins - genetics; Sp1 Transcription Factor - genetics; Transfection; 乳香树胶; 前列腺癌细胞; 基因表达; 肿瘤抑制基因

Aim： To study whether gum mastic, a natural resin, can regulate maspin expression in prostate cancer cells, and further investigate the mechanisms involved in this regulatory system. Methods： RT-PCR and Western blotting were used to detect maspin expression at the transcriptional and translational l...