Adipose-derived mesenchymal stem cells slow disease progression of acute-on-chronic liver failure
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| Published in | Biomedicine & pharmacotherapy Vol. 91; pp. 776 - 787 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
France
Elsevier Masson SAS
01.07.2017
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| AbstractList | A serious complication of chronic hepatic insufficiency is acute-on-chronic liver failure, a recognized syndrome characterized by acute decompensation of cirrhosis and organ/system failure. We investigated the use of adipose-derived mesenchymal stem cells (AD-MSCs) in an experimental model of acute-on-chronic liver failure, developed by microsurgical extrahepatic cholestasis in rats. Rats undergoing microsurgical extrahepatic cholestasis were treated by intraparenchymal liver injection of human or rat AD-MSCs, undifferentiated or previously differentiated in vitro toward the hepatocyte lineage. The groups treated with rat AD-MSCs showed less ascites, lower hepato- and splenomegaly, less testicular atrophy, and an improvement in serum biochemical hepatic parameters. There was also an improvement in histological liver changes, in which the area of fibrosis and bile duct proliferation were significantly decreased in the group treated with predifferentiated rat AD-MSCs. In conclusion, an isograft of hepatocyte-predifferentiated AD-MSCs injected intraparenchymally 2 weeks after microsurgery in extrahepatic cholestatic rats prevents secondary complications of acute-on-chronic hepatic failure. These data support the potential use of autologous AD-MSCs in the treatment of human cholestasis, and specifically of newborn biliary atresia, which could be beneficial for patients awaiting transplant. [Display omitted] A serious complication of chronic hepatic insufficiency is acute-on-chronic liver failure, a recognized syndrome characterized by acute decompensation of cirrhosis and organ/system failure. We investigated the use of adipose-derived mesenchymal stem cells (AD-MSCs) in an experimental model of acute-on-chronic liver failure, developed by microsurgical extrahepatic cholestasis in rats. Rats undergoing microsurgical extrahepatic cholestasis were treated by intraparenchymal liver injection of human or rat AD-MSCs, undifferentiated or previously differentiated in vitro toward the hepatocyte lineage. The groups treated with rat AD-MSCs showed less ascites, lower hepato- and splenomegaly, less testicular atrophy, and an improvement in serum biochemical hepatic parameters. There was also an improvement in histological liver changes, in which the area of fibrosis and bile duct proliferation were significantly decreased in the group treated with predifferentiated rat AD-MSCs. In conclusion, an isograft of hepatocyte-predifferentiated AD-MSCs injected intraparenchymally 2 weeks after microsurgery in extrahepatic cholestatic rats prevents secondary complications of acute-on-chronic hepatic failure. These data support the potential use of autologous AD-MSCs in the treatment of human cholestasis, and specifically of newborn biliary atresia, which could be beneficial for patients awaiting transplant. Graphical abstract |
| Author | Fuentes-Julian, Sherezade Gilsanz, Carlos Aller, Maria-Angeles Argudo, Salvador Beleña, Jose Blázquez-Martinez, Alejandro Fernández-Delgado, Jorge Arias, Jaime De Miguel, María P Prieto, Isabel |
| Author_xml | – sequence: 1 fullname: Gilsanz, Carlos – sequence: 2 fullname: Aller, Maria-Angeles – sequence: 3 fullname: Fuentes-Julian, Sherezade – sequence: 4 fullname: Prieto, Isabel – sequence: 5 fullname: Blázquez-Martinez, Alejandro – sequence: 6 fullname: Argudo, Salvador – sequence: 7 fullname: Fernández-Delgado, Jorge – sequence: 8 fullname: Beleña, Jose – sequence: 9 fullname: Arias, Jaime – sequence: 10 fullname: De Miguel, María P |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28501004$$D View this record in MEDLINE/PubMed |
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| Keywords | Animal models Adipose derived stem cells Liver regeneration Cellular therapy Mesenchymal stem cells |
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| Snippet | Graphical abstract [Display omitted] A serious complication of chronic hepatic insufficiency is acute-on-chronic liver failure, a recognized syndrome characterized by acute... A serious complication of chronic hepatic insufficiency is acute-on-chronic liver failure, a recognized syndrome characterized by acute decompensation of... |
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| SubjectTerms | Acute-On-Chronic Liver Failure - blood Acute-On-Chronic Liver Failure - pathology Acute-On-Chronic Liver Failure - therapy Adipose derived stem cells Animal models Animals Body Weight Cell Differentiation Cellular therapy Disease Progression Humans Internal Medicine Kaplan-Meier Estimate Liver - pathology Liver regeneration Male Medical Education Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Organ Size Rats, Wistar Survival Analysis |
| Title | Adipose-derived mesenchymal stem cells slow disease progression of acute-on-chronic liver failure |
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