Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A

• Published in: Cell cycle (Georgetown, Tex.) Vol. 23; no. 3; pp. 279 - 293
• Main Authors: Wójcik, Michał, Zmarzły, Nikola, Derkacz, Alicja, Kulpok-Bagiński, Tomasz, Blek, Natasza, Grabarek, Beniamin Oskar
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.02.2024
• Subjects: bacterial lipopolysaccharide A; Cell Line; Cyclosporine - pharmacology; cyclosporine A; Dual Specificity Phosphatase 1 - genetics; Dual Specificity Phosphatase 1 - metabolism; Dual-Specificity Phosphatases - genetics; Dual-Specificity Phosphatases - metabolism; Gene Expression Profiling; Gene Expression Regulation - drug effects; HaCaT Cells; Humans; Keratinocytes - drug effects; Keratinocytes - metabolism; Lipopolysaccharides - pharmacology; MicroRNAs - genetics; MicroRNAs - metabolism; Mitogen-Activated Protein Kinase Phosphatases - genetics; Mitogen-Activated Protein Kinase Phosphatases - metabolism; Mitogen-activated protein kinases; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; Psoriasis - drug therapy; Psoriasis - genetics; Research Paper; Transcriptome - drug effects; Transcriptome - genetics; bacterial lipopolysaccharide A; cyclosporine A; Mitogen-activated protein kinases

Studies indicate that mitogen-activated protein kinases (MAPKs) are activated and overexpressed in psoriatic lesions. The aim of the study was to assess changes in the expression pattern of genes encoding MAPKs and microRNA (miRNA) molecules potentially regulating their expression in human adult low...