Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 46; no. 48; pp. 16973 - 16982
• Main Authors: Price, Thomas W., Gallo, Juan, Kubíček, Vojtěch, Böhmová, Zuzana, Prior, Timothy J., Greenman, John, Hermann, Petr, Stasiuk, Graeme J.
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 2017
• Subjects: Amino acids; Chelates; Complexation; Derivatives; Gallium; Radiochemistry

Gallium-68 ( 68 Ga) has been the subject of increasing interest for its potential in the production of radiotracers for diagnosis of diseases. In this work we report the complexation of 68 Ga by the amino acid based tripodal chelate H 3 Dpaa, and two bifunctional derivatives, H 3 Dpaa.dab and H 4 Dp...