Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease - Zhou, Yumin; Zhong, Nan-shan; Li, Xiaochen; Chen, Shuyun; Zheng, Jinping; Zhao, Dongxing; Yao, Weimin; Zhi, Rongchang; Wei, Liping; He, Bingwen; Zhang, Xiangyan; Yang, Changli; et al. (The New England journal of medicine, 2017)
Keywords: Administration, Inhalation; Aged; Bronchodilator Agents - adverse effects; Bronchodilator Agents - therapeutic use; Bronchodilators; Chronic obstructive pulmonary disease; Clinical trials; Disease Progression; Double-Blind Method; Drug therapy; Female; Forced Expiratory Volume - drug effects; Humans; Lung diseases; Male; Middle Aged; Obstructive lung disease; Pharmaceuticals; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - physiopathology; Quality of Life; Respiratory function; Tiotropium Bromide - adverse effects; Tiotropium Bromide - therapeutic use