Identification of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) for susceptibility to schizophrenia in a Han Chinese population

• Published in: The world journal of biological psychiatry Vol. 13; no. 2; pp. 106 - 113
• Main Authors: Zhang, Huaihui, Li, Dawei, Su, Yousong, Jiang, Sanduo, Xu, Yifeng, Jiang, Kaida, Cui, Donghong
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.02.2012; Taylor & Francis
• Subjects: Acid Ceramidase - genetics; Adult; ASAH1; Asian Continental Ancestry Group - genetics; association; China; Chinese; Down-Regulation; Female; Gene Expression Profiling; Genetic Predisposition to Disease - ethnology; Haplotypes; Humans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; schizophrenia; Schizophrenia - ethnology; Schizophrenia - genetics; susceptibility; China

Abstract Objectives. To study the involvement of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) in the susceptibility to schizophrenia in the Han Chinese population. Methods. We performed cDNA microarray analysis to exam the gene expression profile in six schizophrenic patients and six healthy...