Correlation of Meropenem Plasma Levels with Pharmacodynamic Requirements in Critically Ill Patients Receiving Continuous Veno-Venous Hemofiltration

• Published in: Chemotherapy (Basel) Vol. 49; no. 6; pp. 280 - 286
• Main Authors: Krueger, Wolfgang A., Neeser, Gertraud, Schuster, Harald, Schroeder, Torsten H., Hoffmann, Edgar, Heininger, Alexandra, Dieterich, Hans-Juergen, Forst, Helmuth, Unertl, Klaus E.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.12.2003; S. Karger AG
• Subjects: Acute Kidney Injury - complications; Acute Kidney Injury - therapy; Aged; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Infections - drug therapy; Biological and medical sciences; Critical Illness; Drug Administration Schedule; Female; Half-Life; Hemofiltration; Humans; Male; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Pharmacology; Pharmacology. Drug treatments; Thienamycins - pharmacokinetics; Thienamycins - pharmacology; Renal replacement therapies; Hemofiltration; Meropenem pharmacokinetics; Multiple organ failure; ICU infection treatment; Acute kidney failure; Carbapenems; Kidney disease; Human; Pharmacokinetic pharmacodynamic relationship; Urinary system disease; Intravenous administration; Critically ill; Hemofiltration Multiple organ failure ICU infection treatment; β-Lactams; Posology; Infection; Extrarenal dialysis; Antibiotic; Carbapenem derivatives; Chemotherapy; Treatment; Activity concentration relation; Renal failure; Acute kidney failure Renal replacement therapies; Meropenem; Antibacterial agent; Pharmacokinetics; Carbapenems Meropenem pharmacokinetics

Background: In patients with acute renal failure, the pharmacokinetics of meropenem depend on the operational characteristics of the renal replacement therapy. Dosage recommendations are based on the correlation of plasma levels with pharmacodynamic requirements. Methods: Eight critically ill patien...