Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques

• Published in: Frontiers in immunology Vol. 12; p. 810047
• Main Authors: Madden, Patrick J, Arif, Muhammad S, Becker, Mark E, McRaven, Michael D, Carias, Ann M, Lorenzo-Redondo, Ramon, Xiao, Sixia, Midkiff, Cecily C, Blair, Robert V, Potter, Elizabeth Lake, Martin-Sancho, Laura, Dodson, Alan, Martinelli, Elena, Todd, John-Paul M, Villinger, Francois J, Chanda, Sumit K, Aye, Pyone Pyone, Roy, Chad J, Roederer, Mario, Lewis, Mark G, Veazey, Ronald S, Hope, Thomas J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.12.2021
• Subjects: Animals; antibodies; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody probes; Cell Line; COVID-19; COVID-19 - pathology; Disease Models, Animal; Fluorescent Antibody Technique - methods; Humans; Immunology; Lung - pathology; Lung - virology; Macaca mulatta; nonhuman primates; Proof of Concept Study; rhesus macaque; SARS-CoV-2; SARS-CoV-2 - growth & development; Spike Glycoprotein, Coronavirus - immunology; Viral Load - methods; Virus Replication - physiology; COVID-19; SARS-CoV-2; rhesus macaque; antibodies; nonhuman primates; antibody probes

Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when...