PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis - Ihara, Shinji; Nakayama, Sohei; Murakami, Yoshiko; Suzuki, Emiko; Asakawa, Masayo; Kinoshita, Taroh; Sawa, Hitoshi (Journal of cell science, 2017)
Keywords: Agglomeration; Anchors; Animals; Biosynthesis; Caenorhabditis elegans - cytology; Caenorhabditis elegans - metabolism; Caenorhabditis elegans - ultrastructure; Caenorhabditis elegans Proteins - metabolism; Conserved Sequence; CRISPR; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum - ultrastructure; Evolution, Molecular; Glycosylphosphatidylinositol; Glycosylphosphatidylinositols - metabolism; HEK293 Cells; Humans; Intracellular Membranes - metabolism; Intracellular Space - metabolism; Mammalian cells; Mutation; Mutation - genetics; Nematodes; Phosphotransferases - chemistry; Phosphotransferases - metabolism; Protein Aggregates; Protein interaction; Proteins; Quality control; Sequence Homology, Amino Acid; GPI; MCAHS1 patients; Protein aggregation; PIGN; Endoplasmic reticulum