Autocrine inhibition of parathyroid cell secretion requires proteolytic processing of chromogranin A

• Published in: Bone and mineral Vol. 17; no. 3; pp. 323 - 333
• Main Authors: Fasciotto, Brigitte H., Gorr, Sven-Ulrik, Cohn, David V.
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.06.1992; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Autocrine inhibition; Biological and medical sciences; Cells, Cultured; Chromogranin A; Chromogranins - metabolism; Chromogranins - secretion; Fundamental and applied biological sciences. Psychology; Hormone processing; Hormones. Regulation; Pancreastatin; Parathormone; Parathyroid Glands - cytology; Parathyroid Glands - enzymology; Parathyroid Glands - secretion; Parathyroid secretion; Peptide Hydrolases - drug effects; Peptide Hydrolases - metabolism; Precipitin Tests; Protease Inhibitors - pharmacology; Protein Processing, Post-Translational; Proteolysis; Swine; Thyroid. Parathyroid. Ultimobranchial body; Vertebrates: endocrinology; Autocrine inhibition; Parathyroid secretion; Parathormone; Hormone processing; Chromogranin A; Proteolysis; Pancreastatin; Endocrine cell; Molecular processing; Pore; Parathyroid glands; Prohormone

Chromogranin A (CgA, Secretory Protein-I) is a protein of about 450 amino acids representing a major soluble component of the secretory granules of parathyroid and other endocrine and neuroendocrine cells. In the parathyroid, CgA is costored and cosecreted with parathormone (PTH). We earlier found t...