Ribosome-inactivating proteins Potent poisons and molecular tools

• Published in: Virulence Vol. 4; no. 8; pp. 774 - 784
• Main Authors: Walsh, Matthew J, Dodd, Jennifer E, Hautbergue, Guillaume M
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 15.11.2013; Landes Bioscience
• Subjects: abrin; analytical and therapeutic applications; Bacterial Toxins - metabolism; biological weapon; BLF1; BPSL1549; eukaryotic protein synthesis inhibition; Humans; Poisons - toxicity; Protein Synthesis Inhibitors - toxicity; Ribosome Inactivating Proteins - toxicity; ricin; RNA, Ribosomal, 28S - metabolism; saporin; Shiga toxins; Special Focus Review; α-sarcin; abrin; biological weapon; ricin; BPSL1549; analytical and therapeutic applications; α-sarcin; BLF1; Shiga toxins; saporin; eukaryotic protein synthesis inhibition

Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of atomic structures and molecular mechanism has revealed these proteins to be a diverse group subdivided into two class...