Adenosine 5′-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy

• Published in: Journal of dairy science Vol. 104; no. 4; pp. 4516 - 4528
• Main Authors: Xu, Qiushi, Fan, Yunhui, Loor, Juan J., Liang, Yusheng, Sun, Xudong, Jia, Hongdou, Zhao, Chenxu, Xu, Chuang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2021
• Subjects: Adenosine; adipocytes; Adipocytes - metabolism; adipose tissue; AMPK; Animals; antioxidant activity; Antioxidants; Autophagy; basic-leucine zipper transcription factors; blood serum; catalase; Cattle; dairy science; Female; genes; glutathione peroxidase; glutathione transferase; heme oxygenase (biliverdin-producing); Holstein; homeostasis; Hydrogen Peroxide; Kelch-Like ECH-Associated Protein 1 - metabolism; ketosis; malondialdehyde; NF-E2-Related Factor 2 - metabolism; NFE2L2; Oxidative Stress; Protein Kinases; Reactive Oxygen Species - metabolism; superoxide dismutase; AMPK; autophagy; adipocytes; NFE2L2

Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysr...