REM sleep deprivation (REMSD) antagonizes naloxone-precipitated withdrawal in acute morphine-dependent rats

In rats allowed undisturbed sleep (control and stress) the administration of naloxone (10 mg/kg, s.c.) to morphine (7.5 mg/kg, s.c. 90 min prior) pretreated animals precipitated a jumping behaviour. REM sleep deprivation (REMSD 96 h, prior) significantly decreased the frequency of the naloxone-preci...

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Bibliographic Details
Published inPharmacological research communications Vol. 18; no. 9; p. 857
Main Authors Dzoljic, M R, van Meurs, P A, Ukponmwan, O E
Format Journal Article
LanguageEnglish
Published United States 01.09.1986
Subjects
Animals
Male
Morphine Dependence - psychology
Motor Activity
Naloxone - pharmacology
Protein Biosynthesis
Rats
Rats, Inbred Strains
Sleep Deprivation
Sleep, REM
Stress, Physiological - psychology
Substance Withdrawal Syndrome
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Summary:In rats allowed undisturbed sleep (control and stress) the administration of naloxone (10 mg/kg, s.c.) to morphine (7.5 mg/kg, s.c. 90 min prior) pretreated animals precipitated a jumping behaviour. REM sleep deprivation (REMSD 96 h, prior) significantly decreased the frequency of the naloxone-precipitated jumping behaviour compared with control and stressed animals. In second animal model for morphine withdrawal, naloxone (10 mg/kg, s.c.) provoked myoclonic twitch activity (MTA) in rats previously exposed to morphine (7.5 mg/kg, s.c., 90 min prior). The intensity of naloxone-induced MTA in REM sleep deprived rats was significantly lower compared to stressed animals, but it is not different from the control group. It is suggested that REMSD interferes with a neural mechanism involved in the development of acute dependence. Results are discussed in light of a possible functional insufficiency of a mu-opioid system during REMSD.
ISSN:0031-6989
DOI:10.1016/0031-6989(86)90135-9