CARDIORESPIRATORY EFFECTS OF ANAESTHESIA WITH MORPHINE OR FENTANYL IN CHRONIC RENAL FAILURE AND CEREBRAL TOXICITY AFTER MORPHINE

• Published in: British journal of anaesthesia : BJA Vol. 43; no. 11; pp. 1053 - 1060
• Main Authors: MOSTERT, J.W., EVERS, J.L., HOBIKA, G.H., MOORE, R.H., AMBRUS, J.L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.1971; Oxford University Press
• Subjects: Anesthesia, Intravenous; Blood Pressure; Blood Volume; Carbon Dioxide - blood; Cardiac Output; Coma - chemically induced; Fentanyl; Half-Life; Heart Rate; Hemodynamics; Humans; Hydrogen-Ion Concentration; Kidney Failure, Chronic; Morphine - adverse effects; Morphine - metabolism; Nitrogen - blood; Oxygen - blood; Partial Pressure; Succinylcholine; Time Factors; Uremia; Vascular Resistance

Three patients with chronic renal failure received fentanyl 0.5 mg and suxamethonium 40 mg intravenously. Vasoactivity attributed to suxamethonium and loss of consciousness were noted. Cardiorespiratory effects of unsupplemented fentanyl 0.5 mg injected slowly were not significant in four chronicall...