Defective Interfering Influenza Virus RNAs: Time To Reevaluate Their Clinical Potential as Broad-Spectrum Antivirals?

• Published in: Journal of virology Vol. 88; no. 10; pp. 5217 - 5227
• Main Authors: Dimmock, Nigel J., Easton, Andrew J.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.05.2014
• Subjects: Animals; Antiviral Agents - therapeutic use; Biological Products - therapeutic use; Biomedical Research - trends; Defective Viruses - physiology; Disease Models, Animal; Genome and Regulation of Viral Gene Expression; Influenza A virus; Orthomyxoviridae - physiology; Orthomyxoviridae Infections - therapy; Viral Interference

Defective interfering (DI) RNAs are highly deleted forms of the infectious genome that are made by most families of RNA viruses. DI RNAs retain replication and packaging signals, are synthesized preferentially over infectious genomes, and are packaged as DI virus particles which can be transmitted t...